INT106036

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PEPD) cellular amino acid metabolic process (PEPD)
Anatomy Link Frequency
pancreas 2
PEPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Paroxysmal extreme pain disorder 42 100.00 Very High Very High Very High
Nav1.7 30 100.00 Very High Very High Very High
addiction 15 98.88 Very High Very High Very High
carbamazepine 11 93.12 High High
dorsal root ganglion 32 76.32 Quite High
sodium channel 9 74.36 Quite High
Nav1.9 1 55.32 Quite High
nav1.8 1 54.88 Quite High
Chronic pancreatitis 1 50.00 Quite Low
Pain 20 32.36 Quite Low
Disease Link Frequency Relevance Heat
Somatoform Disorder 42 100.00 Very High Very High Very High
Pancreatic Cancer 2 79.04 Quite High
Erythermalgia 16 78.88 Quite High
Pancreatitis 2 78.16 Quite High
Ganglion Cysts 33 76.32 Quite High
Disease 5 17.84 Low Low
Pain 17 5.00 Very Low Very Low Very Low
Erythema 4 5.00 Very Low Very Low Very Low
Heart Rate Under Development 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In pancreatitis tissue, an increase in collagen content, collagenolytic activity and beta 1 integrin expression were accompanied by significant decrease (about 2-fold) in prolidase activity and marked decrease in its expression, compared to normal pancreas.
Negative_regulation (decrease) of Negative_regulation (decrease) of prolidase in pancreas
1) Confidence 0.42 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.16 Pain Relevance 0
Our observations of a 19 mV depolarizing shift in the voltage-dependence of fast-inactivation for M1627K confirm the linkage of impaired fast-inactivation of Nav1.7 and PEPD reported by Fertleman et al [19].
Negative_regulation (impaired) of Negative_regulation (inactivation) of PEPD associated with addiction, paroxysmal extreme pain disorder and nav1.7
2) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.52 Pain Relevance 0.98

General Comments

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