INT106037

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.18
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PEPD) cellular amino acid metabolic process (PEPD)
Anatomy Link Frequency
fibroblasts 3
pancreas 2
neurons 1
PEPD (Homo sapiens)
PEPD - V1298F (1)
Pain Link Frequency Relevance Heat
Paroxysmal extreme pain disorder 148 100.00 Very High Very High Very High
Nav1.7 62 99.98 Very High Very High Very High
Pain 72 99.12 Very High Very High Very High
dorsal root ganglion 126 98.84 Very High Very High Very High
repetitive firing 6 96.52 Very High Very High Very High
sodium channel 36 91.60 High High
Nav1.1 2 90.80 High High
Action potential 48 88.96 High High
hyperexcitability 14 76.96 Quite High
nociceptor 8 68.16 Quite High
Disease Link Frequency Relevance Heat
Somatoform Disorder 148 100.00 Very High Very High Very High
Erythermalgia 94 100.00 Very High Very High Very High
Pain 72 99.12 Very High Very High Very High
Ganglion Cysts 132 98.84 Very High Very High Very High
Hypopituitarism 2 95.20 Very High Very High Very High
Pancreatic Cancer 6 93.28 High High
Pancreatitis 6 92.40 High High
Epilepsy 2 91.68 High High
Syndrome 4 80.56 Quite High
Disease 13 57.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These phenomena were accompanied by over 10-fold decrease in prolidase activity and marked decrease in prolidase expression.
Gene_expression (expression) of prolidase
1) Confidence 0.75 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.12 Pain Relevance 0
MATERIAL/METHODS: Control and acetylsalicylic acid-treated confluent human skin fibroblasts were compared with respect to collagen biosynthesis ([3H]proline incorporation assay), prolidase activity (colorimetric assay) and the expressions of prolidase and some signaling proteins (Western immunoblot analysis).
Gene_expression (expressions) of prolidase in fibroblasts
2) Confidence 0.71 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
METHODOLOGY: Ten human samples of advanced chronic pancreatitis and pancreatic cancer and ten samples of normal pancreas were compared in respect to prolidase activity and expression (western immunoblot), collagen content (hydroxyproline determination), collagenolytic activity (zymography) and beta 1 integrin subunit expression (western immunoblot).
Gene_expression (expression) of prolidase in pancreas
3) Confidence 0.65 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.19 Pain Relevance 0
METHODOLOGY: Ten human samples of advanced chronic pancreatitis and pancreatic cancer and ten samples of normal pancreas were compared in respect to prolidase activity and expression (western immunoblot), collagen content (hydroxyproline determination), collagenolytic activity (zymography) and beta 1 integrin subunit expression (western immunoblot).
Gene_expression (expression) of prolidase in pancreas
4) Confidence 0.65 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.19 Pain Relevance 0
MATERIAL/METHODS: Control and acetylsalicylic acid-treated confluent human skin fibroblasts were compared with respect to collagen biosynthesis ([3H]proline incorporation assay), prolidase activity (colorimetric assay) and the expressions of prolidase and some signaling proteins (Western immunoblot analysis).
Gene_expression (biosynthesis) of prolidase in fibroblasts
5) Confidence 0.61 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
RESULTS: In cells treated with acetylsalicylic acid, a concomitant decrease in prolidase activity, prolidase phosphorylation (at the threonine residue), and collagen biosynthesis were observed.
Gene_expression (biosynthesis) of prolidase
6) Confidence 0.61 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The inhibitory effect of acetylsalicylic acid on collagen biosynthesis in fibroblasts is coupled to the inhibition of prolidase phosphorylation (but not expression) and down-regulation of the intracellular signal transmitted by the b1-integrin receptor.


Neg (not) Gene_expression (expression) of prolidase in fibroblasts
7) Confidence 0.55 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
Interestingly, substitution of the first methionine (Ma) in this linker (Figure 1C) with a positively charged residue (M1627K) in Nav1.7 causes PEPD ([19] and this study), while substitution with a hydrophobic residue isoleucine (M1476I) in Nav1.4 causes cold-induced myotonia [42].
Gene_expression (causes) of PEPD associated with paroxysmal extreme pain disorder, hypopituitarism and nav1.7
8) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.55 Pain Relevance 0.48
Indeed, we now show in this study that a PEPD mutation in human Nav1.7 channels in DRG neurons renders these cells hyperexcitable.
Gene_expression (mutation) of PEPD in neurons associated with dorsal root ganglion, paroxysmal extreme pain disorder and nav1.7
9) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 1.10 Pain Relevance 1.17
The electrophysiological properties of wild-type (WT) or mutant NaV1.7R channels were investigated using whole-cell voltage-clamp recording in HEK293 cells stably expressing WT, P1308L (IEM), or V1298F (PEPD) channels.
Gene_expression (expressing) of PEPD associated with paroxysmal extreme pain disorder and erythermalgia
10) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.45 Pain Relevance 0.38
To better understand how these mutations within the same part of the channel cause distinct pain symptoms, we compared electrophysiological properties of P1308L (IEM) and V1298F (PEPD) mutant channels using voltage- and current-clamp recordings.
Gene_expression (properties) of PEPD (V1298F) associated with pain, paroxysmal extreme pain disorder and erythermalgia
11) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 1.58 Pain Relevance 1.08

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