INT106039

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.37
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PEPD) cellular amino acid metabolic process (PEPD)
Anatomy Link Frequency
neurons 2
fibroblasts 2
PEPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Paroxysmal extreme pain disorder 42 100.00 Very High Very High Very High
dorsal root ganglion 32 100.00 Very High Very High Very High
Nav1.7 30 100.00 Very High Very High Very High
repetitive firing 2 96.52 Very High Very High Very High
Action potential 14 92.80 High High
Nav1.1 1 90.80 High High
nociceptor 4 68.16 Quite High
hyperexcitability 5 63.12 Quite High
addiction 15 54.52 Quite High
aspirin 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Somatoform Disorder 42 100.00 Very High Very High Very High
Ganglion Cysts 33 100.00 Very High Very High Very High
Epilepsy 1 91.68 High High
Erythermalgia 16 72.96 Quite High
Pancreatic Cancer 4 64.72 Quite High
Pancreatitis 4 63.84 Quite High
Disease 6 57.64 Quite High
Pain 17 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Erythema 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These phenomena were accompanied by over 10-fold decrease in prolidase activity and marked decrease in prolidase expression.
Negative_regulation (decrease) of Gene_expression (expression) of prolidase
1) Confidence 0.56 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.13 Pain Relevance 0
These phenomena were accompanied by over 10-fold decrease in prolidase activity and marked decrease in prolidase expression.
Negative_regulation (decrease) of Gene_expression (expression) of prolidase
2) Confidence 0.42 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.13 Pain Relevance 0
CONCLUSIONS: The inhibitory effect of acetylsalicylic acid on collagen biosynthesis in fibroblasts is coupled to the inhibition of prolidase phosphorylation (but not expression) and down-regulation of the intracellular signal transmitted by the b1-integrin receptor.


Negative_regulation (inhibition) of Neg (not) Gene_expression (expression) of prolidase in fibroblasts
3) Confidence 0.39 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
RESULTS: In cells treated with acetylsalicylic acid, a concomitant decrease in prolidase activity, prolidase phosphorylation (at the threonine residue), and collagen biosynthesis were observed.
Negative_regulation (decrease) of Gene_expression (biosynthesis) of prolidase
4) Confidence 0.39 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
Indeed, we now show in this study that a PEPD mutation in human Nav1.7 channels in DRG neurons renders these cells hyperexcitable.
Negative_regulation (renders) of Gene_expression (mutation) of PEPD in neurons associated with dorsal root ganglion, paroxysmal extreme pain disorder and nav1.7
5) Confidence 0.18 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 1.11 Pain Relevance 1.18

General Comments

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