INT10604

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 0.72
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1A2) small molecule metabolic process (SULT1A2) cytoplasm (SULT1A2)
Anatomy Link Frequency
keratinocyte 3
feces 1
liver 1
brain 1
SULT1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 2 93.52 High High
Paracetamol 21 92.08 High High
Dopamine 1 87.36 High High
Potency 12 85.52 High High
agonist 39 83.48 Quite High
Enkephalin 3 66.72 Quite High
Cholecystokinin 1 63.92 Quite High
Bile 27 58.36 Quite High
opioid receptor 3 25.00 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Constipation 1 98.16 Very High Very High Very High
Cancer 21 87.60 High High
Schizophrenia 1 82.88 Quite High
Van Bogaert's Disease 21 77.44 Quite High
Targeted Disruption 8 70.64 Quite High
Neurodegenerative Disease 1 70.64 Quite High
Wound Healing 3 65.92 Quite High
Gallstones 6 59.68 Quite High
Toxicity 12 58.92 Quite High
Nicotine Addiction 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bacterial expression of human phenol phenolsulfotransferase (P-PST) has provided the opportunity to understand better the catalytic properties and biological role of this enzyme.
Gene_expression (expression) of P-PST
1) Confidence 0.76 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8937850 Disease Relevance 0 Pain Relevance 0
Bacterial expression of human phenol phenolsulfotransferase (P-PST) has provided the opportunity to understand better the catalytic properties and biological role of this enzyme.
Gene_expression (expression) of phenol phenolsulfotransferase
2) Confidence 0.66 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8937850 Disease Relevance 0 Pain Relevance 0
Sodium picosulfate, a laxative, was biotransformed to 4,4'-dihydroxydiphenyl-(2 pyridyl)-methane by intestinal flora that produced a novel sulfotransferase (not sulfatase).
Neg (not) Gene_expression (produced) of sulfotransferase associated with constipation
3) Confidence 0.51 Published 1992 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1507649 Disease Relevance 0.10 Pain Relevance 0.09
Very similar results were obtained in a comparison of cells expressing CYP1A2 and aryl sulfotransferase.
Gene_expression (expressing) of aryl sulfotransferase
4) Confidence 0.22 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.05 Pain Relevance 0.07
Transfection of UV5 cells with mouse P450 1A2 complementary DNA established the UV5P3 line (72), which was subsequently transfected with human aryl sulfotransferase (HAST1) or NAT2 from a human liver complementary DNA library (70,73), producing CHO cells that are NER deficient (or proficient) and express mouse P4501A2 plus human aryl sulfotransferase or NAT genes.
Gene_expression (express) of aryl sulfotransferase in liver
5) Confidence 0.15 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0.03
Substrate specificity of a novel sulfotransferase produced by Eubacterium A-44 isolated from human feces has been studied.
Gene_expression (produced) of sulfotransferase in feces
6) Confidence 0.09 Published 1991 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1799945 Disease Relevance 0 Pain Relevance 0.23
Particularly in keratinocytes which rely on lipid signaling for the progression of programmed cellular differentiation, the inducible expression of cholesterol sulfotransferase (SULT2B1b) by PPAR activators has been demonstrated.
Gene_expression (expression) of sulfotransferase in keratinocytes
7) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.27 Pain Relevance 0.07
Exposure of fetal rat skin explants to air caused the accelerated expression of cholesterol sulfotransferase along with several other markers of keratinocyte differentiation, including filaggrin, loricrin and involucrin [61].
Gene_expression (expression) of sulfotransferase in keratinocyte
8) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.15 Pain Relevance 0
In 1984, an enzyme capable of sulfonating cholesterol was reported to be present in mouse epidermis [56], and several subsequent pieces of evidence have supported the concept that “cholesterol sulfotransferase” expression and cholesterol 3-sulfate production are events that are closely linked to keratinocyte differentiation.
Gene_expression (expression) of sulfotransferase in keratinocyte
9) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.03
The over-expression of the sulfotransferase genes in this study does not correspond to the negative correlation to levels of androstenone previously reported for this enzyme family [48].
Gene_expression (expression) of sulfotransferase
10) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2204014 Disease Relevance 0 Pain Relevance 0
The over-expression of the sulfotransferase genes in this study does not correspond to the negative correlation to levels of androstenone previously reported for this enzyme family [48].
Gene_expression (-) of sulfotransferase
11) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2204014 Disease Relevance 0 Pain Relevance 0
The over-expression of the sulfotransferase genes in this study does not correspond to the negative correlation to levels of androstenone previously reported for this enzyme family [48].
Gene_expression (over) of sulfotransferase
12) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2204014 Disease Relevance 0 Pain Relevance 0
Sulfotransferase 4A1 (SULT4A1) is a novel cytosolic sulfotransferase that is primarily expressed in the brain.
Gene_expression (expressed) of sulfotransferase in brain
13) Confidence 0.01 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox