INT10605

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Context Info
Confidence 0.68
First Reported 1983
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 28
Disease Relevance 17.22
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
Eosinophils 3
PGE2 3
plasma 2
alveolar macrophages 2
mast cells 2
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 651 99.38 Very High Very High Very High
Clonidine 1 99.34 Very High Very High Very High
Inflammation 54 96.56 Very High Very High Very High
substance P 5 95.08 Very High Very High Very High
corticosteroid 77 91.52 High High
Angina 5 89.40 High High
agonist 9 89.32 High High
cINOD 96 89.28 High High
Analgesic 44 87.80 High High
Pain 12 87.36 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 14 99.84 Very High Very High Very High
Occupational Lung Diseases 10 99.78 Very High Very High Very High
Asthma 1107 99.74 Very High Very High Very High
Bacteremia 4 99.70 Very High Very High Very High
Infection 9 99.68 Very High Very High Very High
Disease 76 99.58 Very High Very High Very High
Hypotension 1 99.52 Very High Very High Very High
Polyps 18 99.20 Very High Very High Very High
Recurrence 12 99.20 Very High Very High Very High
Heart Rate Under Development 3 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both compounds increased heart rate at 0.3 microgram/kg bw, but at 3 micrograms/kg bw PGI2 caused greater increases than LTC4.
Positive_regulation (increases) of LTC4 in heart associated with heart rate under development
1) Confidence 0.68 Published 1988 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3133096 Disease Relevance 0.28 Pain Relevance 0.08
The more increase of the LTB4 and LTC4 content in plasma is observed during attacks of fever - 107 + 21 pg/ml (LTB4) and 249 + 34 pg/ml (LTC4).
Positive_regulation (increase) of LTC4 in plasma associated with fever
2) Confidence 0.47 Published 1990 Journal Biull Eksp Biol Med Section Abstract Doc Link 2176555 Disease Relevance 0.27 Pain Relevance 0.09
Guanabenz, but not clonidine, B-HT 920 or B-HT 933 inhibited zymosan-induced LTC4 (IC50 = 13 microM) and PGE2 (IC50 = 10.9 microM) synthesis with no concomitant reduction in zymosan phagocytosis or cell viability.
Positive_regulation (zymosan-induced) of LTC4 associated with clonidine
3) Confidence 0.27 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3121363 Disease Relevance 0.44 Pain Relevance 0.25
This inhalation test was positive and it evoked simultaneous increases of LTC4, LTD4 and histamine in the peripheral blood.
Positive_regulation (increases) of LTC4 in blood
4) Confidence 0.26 Published 1992 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1507696 Disease Relevance 0.65 Pain Relevance 0.20
Patients with sinonasal polyposis with recurrences within 18 months of surgery had higher levels of LTC4 when compared with those patients that did not have recurrences.
Positive_regulation (levels) of LTC4 associated with recurrence
5) Confidence 0.23 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2292155 Disease Relevance 1.62 Pain Relevance 0.12
PGI2 blockade during bacteremia significantly increased LTC4D4E4, and LTB4 whereas PGI2 infusion suppressed LTC4D4E4 concentration, suggesting that endogenous PGI2 may blunt leukotriene release during septic shock.
Positive_regulation (increased) of LTC4D4E4 associated with bacteremia and sepsis
6) Confidence 0.21 Published 2000 Journal Shock Section Abstract Doc Link 10847636 Disease Relevance 0.92 Pain Relevance 0.06
In an examination of 27 patients by Kaplan et al. [33] patients with sinonasal polyps were noted by radioimmunoassay to have elevated levels of LTC4.
Positive_regulation (elevated) of LTC4 associated with polyps
7) Confidence 0.18 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2292155 Disease Relevance 1.50 Pain Relevance 0.12
In contrast to ML3000, indomethacin produced an increase of LTC4 of up to 155.5% of control. 5-lipoxygenase inhibition was further tested in a basophilic leukemia cell assay using RBL-1 cells.
Positive_regulation (increase) of LTC4 in RBL-1
8) Confidence 0.13 Published 2002 Journal Inflamm. Res. Section Body Doc Link 12005204 Disease Relevance 0 Pain Relevance 0
These results indicate that increased gastric content of proinflammatory mediators (LTB4, LTC4, and LT4) may be related to the pathogenesis of H. pylori-associated gastritis.
Positive_regulation (increased) of LTC4 associated with gastritis
9) Confidence 0.12 Published 1999 Journal Turk. J. Pediatr. Section Abstract Doc Link 10770094 Disease Relevance 0.65 Pain Relevance 0.29
Kinetic studies revealed that ionophore stimulated the formation of mainly [3H]-LTE4 with only transient accumulation of [3H]-LTC4 and D4.
Positive_regulation (accumulation) of LTC4
10) Confidence 0.11 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6316436 Disease Relevance 0.09 Pain Relevance 0.09
Plasma levels of TXB2, LTB4, LTC4, peptideLTs from arterial blood significantly increased in AMI patients at the acute stage and one day after an attack of AMI compared with those of normal controls.
Positive_regulation (increased) of LTC4 in Plasma associated with myocardial infarction
11) Confidence 0.09 Published 1991 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 1906069 Disease Relevance 1.09 Pain Relevance 0.27
We suggest that decreases in PGE2 and PGI2 in models of airway disease in combination with increases in LTC4, LTD4, and thromboxane A2 may contribute to airway hyperresponsiveness in vitro.
Positive_regulation (increases) of LTC4 in PGE2 associated with disease
12) Confidence 0.09 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8179018 Disease Relevance 0.10 Pain Relevance 0
CONCLUSION: We conclude that sevoflurane increases pulmonary LTC4, NO3-, and NO2- production in pigs, indicating an inflammatory response.


Positive_regulation (increases) of LTC4
13) Confidence 0.08 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 14674972 Disease Relevance 0 Pain Relevance 0
RESULTS: Compared with thiopentone anaesthesia, significant increases in BAL leukotriene C4 (LTC4), NO3-, and NO2- levels were observed after sevoflurane anaesthesia.
Positive_regulation (increases) of LTC4
14) Confidence 0.08 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 14674972 Disease Relevance 0 Pain Relevance 0
Serine borate (45 mM; an inhibitor of gamma-glutamyl transpeptidase, which prevents the conversion of LTC4 to LTD4) increased selectively the contractile activity of LTC4.
Positive_regulation (increased) of LTC4
15) Confidence 0.08 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8179018 Disease Relevance 0 Pain Relevance 0.22
Cowburn and colleagues demonstrated that although aspirin removes PGE2-dependent suppression in all subjects, only in AEA is there an increase in leukotriene C4 (LTC4) synthase, leading to a marked overproduction of Cys-LTs[45].


Positive_regulation (increase) of LTC4 in PGE2 associated with asthma and aspirin
16) Confidence 0.07 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.68 Pain Relevance 0.21
On mid and distal colonic muscularis mucosae, the actions of LTD4 and LTE4 and, in part, LTC4 are the result of PG production, whereas LTC4 has an additional direct action, possibly mediated through a selective LTC4 receptor.
Positive_regulation (actions) of LTC4
17) Confidence 0.07 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8430808 Disease Relevance 0 Pain Relevance 0.08
Eosinophils, mast cells, and alveolar macrophages use the enzyme LTC4 synthase to conjugate glutathione with LTA4 to make LTC4.
Positive_regulation (make) of LTC4 in alveolar macrophages
18) Confidence 0.06 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.78 Pain Relevance 0.13
Eosinophils, mast cells, and alveolar macrophages use the enzyme LTC4 synthase to conjugate glutathione with LTA4 to make LTC4.
Positive_regulation (enzyme) of LTC4 synthase in alveolar macrophages
19) Confidence 0.06 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.68 Pain Relevance 0.14
Cowburn and colleagues demonstrated that although aspirin removes PGE2-dependent suppression in all subjects, only in AEA is there an increase in leukotriene C4 (LTC4) synthase, leading to a marked overproduction of Cys-LTs[45].


Positive_regulation (increase) of leukotriene C4 in PGE2 associated with asthma and aspirin
20) Confidence 0.06 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.68 Pain Relevance 0.21

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