INT106055

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.64
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
brain 6
hypothalamus 4
neurons 4
cortex 3
puncture 2
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 36 99.92 Very High Very High Very High
Enkephalin 2 99.76 Very High Very High Very High
Morphine 6 99.24 Very High Very High Very High
Dopamine 32 98.82 Very High Very High Very High
Action potential 1 93.88 High High
Ventral tegmentum 5 93.52 High High
monoamine 12 92.40 High High
gABA 39 90.92 High High
antagonist 2 89.76 High High
Periaqueductal grey 2 79.96 Quite High
Disease Link Frequency Relevance Heat
Idiopathic Hypersomnolence 26 99.72 Very High Very High Very High
Sleep Disorders 825 99.60 Very High Very High Very High
Lumbar Puncture Related Headaches 1 98.74 Very High Very High Very High
Death 90 89.56 High High
Targeted Disruption 418 85.68 High High
Ehlers-danlos Syndrome 4 82.68 Quite High
Mental Disorders 2 80.52 Quite High
Urological Neuroanatomy 2 79.96 Quite High
Overdose 8 75.28 Quite High
Hypersomnia 67 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides.
Negative_regulation (reduction) of Gene_expression (producing) of hypocretin in neurons associated with neuropeptide and sleep disorders
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.43 Pain Relevance 0.05
Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain.
Negative_regulation (decline) of Gene_expression (levels) of hypocretin in brain associated with enkephalin
2) Confidence 0.41 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 12399012 Disease Relevance 0 Pain Relevance 0.35
A similar pattern was reported in orexin/hypocretin neurons of the lateral hypothalamus [32, 63].
Negative_regulation (reported) of Gene_expression (neurons) of hypocretin in hypothalamus
3) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701283 Disease Relevance 0.15 Pain Relevance 0.44
A lumbar puncture was performed in 35 patients (19 NC, 7 NWC, 9 HI) in order to measure the CSF hypocretin-1/orexin A levels.
Negative_regulation (measure) of Gene_expression (/) of orexin A in puncture associated with idiopathic hypersomnolence, sleep disorders and lumbar puncture related headaches
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954157 Disease Relevance 1.08 Pain Relevance 0
The sleep disorder narcolepsy is caused by a vast reduction in neurons producing the hypocretin (orexin) neuropeptides.
Negative_regulation (reduction) of Gene_expression (producing) of orexin in neurons associated with neuropeptide and sleep disorders
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.43 Pain Relevance 0.05
Furthermore, the concentrations of HCRT1 and HCRT2 in the cortex and pons, two areas with HCRT projections, are dramatically decreased [7].
Negative_regulation (decreased) of Gene_expression (concentrations) of HCRT1 in cortex
6) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.65 Pain Relevance 0.03
Evaluation of hypocretin and IGFBP3 levels, antibodies and IGFBP3 genotyping
Negative_regulation (Evaluation) of Gene_expression (levels) of hypocretin
7) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.13 Pain Relevance 0
These factors would not be identified in animal models with disrupted hypocretin neurotransmission but would be downregulated in human brains.
Negative_regulation (disrupted) of Gene_expression (neurotransmission) of hypocretin in brains
8) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.38 Pain Relevance 0
We performed gene expression profiling in the hypothalamus to identify novel genes dysregulated in narcolepsy, as these may be the target of autoimmune attack or modulate hypocretin gene expression.


Negative_regulation (modulate) of Gene_expression (expression) of hypocretin in hypothalamus associated with sleep disorders
9) Confidence 0.39 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617764 Disease Relevance 0.57 Pain Relevance 0.04
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Negative_regulation (reaction) of Gene_expression (rabbit) of hypocretin
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.14 Pain Relevance 0
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Negative_regulation (reaction) of Gene_expression (rabbit) of HCRT
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.14 Pain Relevance 0
The loss of HCRT signal is most likely not a simple failure in producing hypocretin peptides alone.
Negative_regulation (failure) of Gene_expression (producing) of hypocretin
12) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.43 Pain Relevance 0.03
We hypothesize that increased IGFBP3 amount in HCRT cells decreases HCRT production and reduces wake under physiological conditions.
Negative_regulation (decreases) of Gene_expression (production) of HCRT
13) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.45 Pain Relevance 0
Furthermore, the increased level of dialysate dopamine produced by morphine in the mouse brain was significantly decreased by deletion of the prepro-orexin gene.
Negative_regulation (decreased) of Gene_expression (deletion) of prepro-orexin in brain associated with dopamine and morphine
14) Confidence 0.28 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16407535 Disease Relevance 0 Pain Relevance 1.06
Furthermore, the concentrations of HCRT1 and HCRT2 in the cortex and pons, two areas with HCRT projections, are dramatically decreased [7].
Negative_regulation (decreased) of in pons Gene_expression (concentrations) of HCRT1 in cortex
15) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.65 Pain Relevance 0.03

General Comments

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