INT10606

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 10.14
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
blood 1
joint 1
cleavages 1
brain 1
hearts 1
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 30 99.32 Very High Very High Very High
Inflammatory mediators 7 98.64 Very High Very High Very High
rheumatoid arthritis 3 98.52 Very High Very High Very High
aspirin 28 98.28 Very High Very High Very High
Inflammation 43 97.96 Very High Very High Very High
Spinal cord 2 97.88 Very High Very High Very High
anesthesia 4 97.26 Very High Very High Very High
cINOD 10 96.32 Very High Very High Very High
tetrodotoxin 4 94.32 High High
Osteoarthritis 2 87.36 High High
Disease Link Frequency Relevance Heat
Bites And Stings 10 99.82 Very High Very High Very High
Nervous System Injury 6 99.56 Very High Very High Very High
Brain Hemorrhage 27 99.32 Very High Very High Very High
Hypersensitivity 6 98.88 Very High Very High Very High
Rheumatoid Arthritis 3 98.52 Very High Very High Very High
INFLAMMATION 61 98.44 Very High Very High Very High
Anaphylaxis 7 97.72 Very High Very High Very High
Arthropathy 4 97.60 Very High Very High Very High
Ulcers 1 96.88 Very High Very High Very High
Apoptosis 1 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Post-anesthesia anaphylactic reactions or those seen during drug provocation tests with a systemic clinical reaction may be confirmed by the sequential release into blood of plasma histamine, tryptase and leukotriene C4 and into urine of urinary methylhistamine and leukotriene E4.
Localization (release) of leukotriene C4 in blood associated with anesthesia and anaphylaxis
1) Confidence 0.75 Published 1998 Journal Allerg Immunol (Paris) Section Abstract Doc Link 9684039 Disease Relevance 0.10 Pain Relevance 0.10
Semi-quantitative RT-PCR revealed that 5-LO, FLAP, LTC4s, BLT1, and CysLT1 mRNAs increased following SNI, but not CysLT2 mRNAs.
Localization (increased) of LTC4s associated with nervous system injury
2) Confidence 0.66 Published 2010 Journal Glia Section Abstract Doc Link 19908283 Disease Relevance 1.10 Pain Relevance 0.60
Release of immunoreactive LTC4-like material was not influenced by the lower concentration of tiaprofenic acid used (2.2 micrograms/min), but significantly enhanced by the higher concentration (10.0 micrograms/min).
Localization (Release) of LTC4-like
3) Confidence 0.62 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3841634 Disease Relevance 0.34 Pain Relevance 0.16
The LTC4 release was significantly lower in inactive rheumatoid arthritis as compared to the other joint diseases.
Localization (release) of LTC4 in joint associated with rheumatoid arthritis and arthropathy
4) Confidence 0.52 Published 1991 Journal Z Orthop Ihre Grenzgeb Section Abstract Doc Link 1837403 Disease Relevance 0.92 Pain Relevance 0.28
The linear regression of statistical analysis, performed to investigate any possible relationship among time-dependent modifications shows that the "ex vivo" release of LTC4 is significantly related to the decreasing trend of MnSOD activity (p < 0.001).
Localization (release) of LTC4
5) Confidence 0.51 Published 1994 Journal Neurochem. Res. Section Abstract Doc Link 7969754 Disease Relevance 0.83 Pain Relevance 0.44
The aim of this work is to investigate whether a correlation exists between time-dependent modifications of eicosanoid peroxide production ("ex vivo" release of leukotriene C4 = LTC4) and antioxidant enzymatic systems in the brain after experimental subarachnoid hemorrhage in the rat.
Localization (release) of LTC4 in brain associated with brain hemorrhage and cva
6) Confidence 0.51 Published 1994 Journal Neurochem. Res. Section Abstract Doc Link 7969754 Disease Relevance 0.80 Pain Relevance 0.44
The release of the LTC4 is significantly enhanced at 1, 6 and 48 hours after SAH induction.
Localization (release) of LTC4 associated with cva
7) Confidence 0.51 Published 1994 Journal Neurochem. Res. Section Abstract Doc Link 7969754 Disease Relevance 0.83 Pain Relevance 0.45
The R(-) enantiomer had no effect on LTC4 release from any of the tissues investigated.
Localization (release) of LTC4
8) Confidence 0.45 Published 1991 Journal Prostaglandins Section Abstract Doc Link 1801061 Disease Relevance 0.20 Pain Relevance 0.03
Moreover, CI-986 inhibited the release of LTC4 and PGE2 by gastric mucosa and reduced mucosal and vascular damage induced by oral administration of absolute ethanol to rats.
Localization (release) of LTC4
9) Confidence 0.44 Published 1994 Journal Prostaglandins Section Abstract Doc Link 8140259 Disease Relevance 1.01 Pain Relevance 0.62
In the second inhalation test, premedication with amlexanox elevated the threshold of sulpyrine and inhibited the release of LTC4, LTD4 and histamine.
Localization (release) of LTC4
10) Confidence 0.27 Published 1992 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1507696 Disease Relevance 0.57 Pain Relevance 0.19
The anti-allergic action of amlexanox is reported to be associated with inhibition of the release of LTC4, LTD4 and histamine, and with antagonistic activity on leukotrienes.
Localization (release) of LTC4 associated with hypersensitivity
11) Confidence 0.27 Published 1992 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1507696 Disease Relevance 0.65 Pain Relevance 0.15
We therefore investigated the effects of the inflammatory mediators, prostaglandin (PGD2, PGE2, PGI2, and PGF2 alpha) and leukotriene (LTC4), on guinea-pig colonic secretion and on electrophysiological behaviour of submucosal neurones.
Localization (secretion) of LTC4 associated with inflammatory mediators
12) Confidence 0.14 Published 1997 Journal Comp. Biochem. Physiol. A Physiol. Section Abstract Doc Link 9366066 Disease Relevance 0.42 Pain Relevance 0.43
The results suggest that LTC4 and D4 evoke anion secretion by acting through distinct LT receptor populations.
Localization (secretion) of LTC4
13) Confidence 0.14 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093730 Disease Relevance 0 Pain Relevance 0.13
LTC4, the primary CysLT product, is secreted by cells and converted extracellularly to LTD4 and LTE4 by successive cleavages of its glutathione moiety.
Localization (secreted) of LTC4 in cleavages
14) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.55 Pain Relevance 0.04
Immediate cutaneous reactions to mosquito bites lead to release of histamine and LTC4, potent mediators of acute allergic processes and inflammation [36].
Localization (release) of LTC4 associated with inflammation, bites and stings and hypersensitivity
15) Confidence 0.04 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.35 Pain Relevance 0.05
A key pathogenic event for aspirin sensitivity is the change of the leukotriene pathway for arachidonic acid metabolism releasing high amounts of leukotrienes LTC4, LTD4 and LTE4, effective chemoattractants and activators of inflammatory cells.
Localization (releasing) of LTC4 associated with aspirin and inflammation
16) Confidence 0.04 Published 1995 Journal Acta Otorhinolaryngol Belg Section Abstract Doc Link 7484142 Disease Relevance 1.11 Pain Relevance 0.71
High concentrations of the acidic drugs phenylbutazone and oxyphenbutazone as well as of the nonacidic metabolites of metamizol, i.e. 4-methylaminoantipyrine and 4-aminoantipyrine, inhibited the release of the cyclo-oxygenase products of arachidonic acid metabolism, TXB2 and 6-keto-PGF1 alpha, and simultaneously increased the release of LTC4-like immunoreactivity in hearts.
Localization (release) of LTC4-like in hearts
17) Confidence 0.03 Published 1986 Journal Agents Actions Suppl. Section Abstract Doc Link 3092600 Disease Relevance 0.38 Pain Relevance 0.22

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