INT106068

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Context Info
Confidence 0.21
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TH) cytosol (TH) mitochondrion (TH)
small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)
TH (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 20 100.00 Very High Very High Very High
Opioid 4 83.12 Quite High
Ventral tegmentum 2 79.04 Quite High
Locus ceruleus 2 77.60 Quite High
Catecholamine 4 75.48 Quite High
orphanin 8 75.00 Quite High
withdrawal 2 64.48 Quite High
analgesia 4 62.04 Quite High
Pain 2 56.32 Quite High
opioid receptor 2 53.92 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 85.52 High High
Pain 2 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine-induced TH upregulation was blocked upon inclusion of a MEK-1 (mitogen-activated protein kinase kinase-1) inhibitor (PD98059), confirming the role for ERKs in this adaptive response to morphine.
Positive_regulation (induced) of Positive_regulation (upregulation) of TH associated with morphine
1) Confidence 0.21 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.14 Pain Relevance 1.41
Inclusion of OFQ/N during chronic morphine exposure also blocked morphine-induced TH upregulation.
Positive_regulation (morphine-induced) of Positive_regulation (upregulation) of TH associated with morphine
2) Confidence 0.15 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.08 Pain Relevance 1.18

General Comments

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