INT106069

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Context Info
Confidence 0.07
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TH, Th) cytoplasm (TH, Th) cytosol (TH, Th)
nucleus (TH, Th) small molecule metabolic process (TH) response to stress (Th)
Anatomy Link Frequency
ventral 1
TH (Homo sapiens)
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 99.84 Very High Very High Very High
Catecholamine 2 98.80 Very High Very High Very High
withdrawal 1 95.36 Very High Very High Very High
Locus ceruleus 1 93.72 High High
analgesia 2 92.92 High High
Ventral tegmentum 1 92.56 High High
Opioid 2 90.84 High High
Pain 1 87.20 High High
opioid receptor 1 84.80 Quite High
orphanin 4 83.28 Quite High
Disease Link Frequency Relevance Heat
Pain 1 87.20 High High
Neuroblastoma 1 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One manifestation of the behavioral changes resulting from chronic use of morphine is the upregulation of tyrosine hydroxylase (TH, the rate-limiting enzyme in catecholamine biosynthesis), which contributes to the dramatic increases in catecholamine release in the target regions of the locus coeruleus (LC) and the ventral tegmental area (VTA).
TH Positive_regulation (upregulation) of tyrosine hydroxylase in ventral associated with ventral tegmentum, locus ceruleus, catecholamine and morphine
1) Confidence 0.07 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399106 Disease Relevance 0.16 Pain Relevance 1.14

General Comments

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