INT106091

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.23
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
urine 2
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 14 100.00 Very High Very High Very High
Action potential 1 99.30 Very High Very High Very High
Kinase C 4 98.74 Very High Very High Very High
dexamethasone 4 98.14 Very High Very High Very High
sodium channel 3 84.00 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Neuronal excitability 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 2 95.24 Very High Very High Very High
Natriuresis 7 76.24 Quite High
Volume Depletion And Dehydration 12 5.00 Very Low Very Low Very Low
Hyponatremia 4 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Overactive Bladder 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that dexamethasone could act on AVP cells independently of action potentials to decrease mRNA stability and to suppress AVP gene transcription during stimulation by cAMP.
Negative_regulation (suppress) of Transcription (transcription) of AVP gene associated with action potential and dexamethasone
1) Confidence 0.59 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.62
In contrast, the MAPK pathway inhibitor, PD98059, profoundly decreased AVP transcription and abolished its daily rhythm.
Negative_regulation (decreased) of Transcription (transcription) of AVP
2) Confidence 0.59 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.50
In contrast, the protein kinase C activator, phorbol 12-myristate 13-acetate, greatly increased AVP transcription in the absence of TTX, but this effect was blocked by TTX, indicating that the phorbol 12-myristate 13-acetate acted indirectly via synaptic input.
Negative_regulation (blocked) of Transcription (transcription) of AVP associated with tetrodotoxin and kinase c
3) Confidence 0.43 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399408 Disease Relevance 0 Pain Relevance 0.60
The maximum rate of urine flow, in the absence of AVP, was fixed at 138 ?
Negative_regulation (fixed) of Neg (absence) Transcription (absence) of AVP in urine
4) Confidence 0.42 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0.23 Pain Relevance 0

General Comments

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