INT106095

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Context Info
Confidence 0.80
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 7.61
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
ARC 3
dendrites 2
hypothalamus 2
plasma 1
CPN 1
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 45 100.00 Very High Very High Very High
nMDA receptor 1 97.68 Very High Very High Very High
long-term potentiation 24 96.08 Very High Very High Very High
Eae 18 95.36 Very High Very High Very High
Glutamate receptor 4 93.92 High High
Hyperalgesia 5 92.96 High High
Intracerebroventricular 7 89.76 High High
mu opioid receptor 5 86.48 High High
Central nervous system 106 84.96 Quite High
tolerance 54 81.00 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 429 100.00 Very High Very High Very High
Hyperalgesia 6 98.52 Very High Very High Very High
Convulsion 1 98.04 Very High Very High Very High
Urological Neuroanatomy 24 88.76 High High
Targeted Disruption 18 87.88 High High
Retinal Degeneration 29 87.12 High High
Hypoglycemia 3 86.60 High High
Impaired Glucose Tolerance 54 81.00 Quite High
Hyperglycemia 9 72.64 Quite High
Hyperinsulinism 9 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used immunocytochemical electron microscopy to determine whether the subcellular localization of Arc in developing dendrites corresponds to the peak period of synaptogenesis in the postnatal rat caudate-putamen nucleus (CPN).
Localization (localization) of Arc in CPN associated with aids-related complex
1) Confidence 0.80 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.39 Pain Relevance 0.16
AIM: The immediate early gene Arc (activity-regulated cytoskeletal-associated protein) mRNA and protein are induced by strong synaptic activation and rapidly transported into dendrites, where they localize at active synaptic sites.
Localization (transported) of Arc in dendrites associated with aids-related complex
2) Confidence 0.75 Published 2009 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 19262551 Disease Relevance 0.35 Pain Relevance 0.26
Arc localizes to the
Localization (localizes) of Arc associated with aids-related complex
3) Confidence 0.74 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.52 Pain Relevance 0.09
Indeed, arc mRNAs localize to dendrites in an activity-dependent manner (Steward et al., 1998).
Localization (localize) of arc in dendrites associated with aids-related complex
4) Confidence 0.73 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.59 Pain Relevance 0
The Arc protein is implicated in control of actin polymerization at synapses
Localization (implicated) of Arc protein in synapses associated with aids-related complex
5) Confidence 0.69 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.54 Pain Relevance 0.19
The regional, normalized homer1a, arc, zif268, ngfi-b, and c-fos expression measurements were used to calculate Pearson product moment correlations with locomotor activity, plasma corticosterone, and gene expression in other regions within the water and Ensure cues groups.
Localization (normalized) of arc in plasma associated with aids-related complex and eae
6) Confidence 0.59 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.10 Pain Relevance 0.05
In addition, this specific localization of Arc mRNA was shown to be dependent on local signaling through the NMDA receptor (Steward and Worley 2001).
Localization (localization) of Arc mRNA associated with aids-related complex and nmda receptor
7) Confidence 0.54 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.79 Pain Relevance 0.05
We conclude that PVN neurons are activated by hyperalgesic IL-1beta and propose that this effect is abolished by alpha-MSH possibly released from the ARC but not from the pituitary gland.
Neg (not) Localization (released) of ARC in pituitary gland associated with hyperalgesia and aids-related complex
8) Confidence 0.39 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16015027 Disease Relevance 0.74 Pain Relevance 0.50
Note the abundance of GLP-1 receptor–expressing cells (green dots) in the periventricular and lateral edge of the ARC (Fig. 4A, C, and D).
Localization (abundance) of ARC in edge associated with aids-related complex
9) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.67 Pain Relevance 0.06
At 120–270 min, GLP-1 was infused into either the i3vt (n = 7), the ARC (n = 7), or the PVN (n = 7) at 0.01 ?
Localization (infused) of ARC associated with aids-related complex
10) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.42 Pain Relevance 0.03
More specifically, restoration of ARC leptin receptors in leptin receptor–deficient mice improves insulin sensitivity independent of changes in food intake (37,38), and insulin, glucose, lactate, or long-chain fatty acid administration directly into the ARC each inhibits glucose production by ?
Localization (receptors) of ARC associated with aids-related complex
11) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.67 Pain Relevance 0.26
Under our experimental conditions we could not detect any significant change in the acetylation of ARC Stat3 by fasting, inhibition of Sirt1, or leptin administration, working against the hypothesis that Sirt1 targets Stat3 in the hypothalamus.
Localization (acetylation) of ARC in hypothalamus associated with aids-related complex
12) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0.03
2 were reported for both the suprachiasmatic nucleus (Sch) and Arc, resepctively.
Localization (reported) of Arc in Arc associated with aids-related complex
13) Confidence 0.12 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2944354 Disease Relevance 0.37 Pain Relevance 0
The high percentage of colocalization of PRs in parvicellular DYN cells of the POA, AHA, and ARC suggests that these cells are prime targets of P.
Localization (colocalization) of ARC in AHA associated with dynorphin and aids-related complex
14) Confidence 0.04 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.29 Pain Relevance 0.53
This observation raises the possibility that an ultrashort feedback loop controls the release of DYN from ARC neurons.
Localization (release) of ARC in ARC associated with dynorphin and aids-related complex
15) Confidence 0.03 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.36 Pain Relevance 0.48
The high percentage of colocalization of PRs in parvicellular DYN cells of the POA, AHA, and ARC suggests that these cells are prime targets of P.
Localization (colocalization) of ARC in POA associated with dynorphin and aids-related complex
16) Confidence 0.01 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.29 Pain Relevance 0.53
The high percentage of colocalization of PRs in parvicellular DYN cells of the POA, AHA, and ARC suggests that these cells are prime targets of P.
Localization (colocalization) of ARC in ARC associated with dynorphin and aids-related complex
17) Confidence 0.01 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.29 Pain Relevance 0.53

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