INT106096

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.79
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
hypothalamus 2
ARC 2
CPN 2
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 11 100.00 Very High Very High Very High
nMDA receptor 1 98.72 Very High Very High Very High
mu opioid receptor 5 89.36 High High
Opioid 2 53.44 Quite High
antagonist 5 53.40 Quite High
Central nervous system 4 42.88 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aids-related Complex 45 100.00 Very High Very High Very High
Convulsion 1 98.04 Very High Very High Very High
Retinal Degeneration 29 89.20 High High
Body Weight 17 59.68 Quite High
Apoptosis 4 41.68 Quite Low
Weight Gain 4 40.56 Quite Low
Stress 4 33.20 Quite Low
Hyperphagia 1 20.08 Low Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used immunocytochemical electron microscopy to determine whether the subcellular localization of Arc in developing dendrites corresponds to the peak period of synaptogenesis in the postnatal rat caudate-putamen nucleus (CPN).
Spec (whether) Regulation (corresponds) of Localization (localization) of Arc in CPN associated with aids-related complex
1) Confidence 0.45 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.39 Pain Relevance 0.16
In addition, this specific localization of Arc mRNA was shown to be dependent on local signaling through the NMDA receptor (Steward and Worley 2001).
Regulation (dependent) of Localization (localization) of Arc mRNA associated with aids-related complex and nmda receptor
2) Confidence 0.41 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699806 Disease Relevance 0.79 Pain Relevance 0.05
Under our experimental conditions we could not detect any significant change in the acetylation of ARC Stat3 by fasting, inhibition of Sirt1, or leptin administration, working against the hypothesis that Sirt1 targets Stat3 in the hypothalamus.
Regulation (change) of Localization (acetylation) of ARC in hypothalamus associated with aids-related complex
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.25 Pain Relevance 0.03
This observation raises the possibility that an ultrashort feedback loop controls the release of DYN from ARC neurons.
Regulation (controls) of Localization (release) of ARC in ARC associated with dynorphin and aids-related complex
4) Confidence 0.01 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.36 Pain Relevance 0.49

General Comments

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