INT10610

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Context Info
Confidence 0.40
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 11.81
Pain Relevance 6.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
plasma 5
blood 3
macrophages 2
hemolymph 1
platelets 1
Plg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 20 99.82 Very High Very High Very High
narcan 6 99.76 Very High Very High Very High
Morphine 8 99.66 Very High Very High Very High
cva 15 98.62 Very High Very High Very High
Peripheral nervous system 16 97.92 Very High Very High Very High
headache 2 97.36 Very High Very High Very High
backache 8 93.52 High High
cINOD 1 93.20 High High
vincristine 1 93.12 High High
Central nervous system 1 92.48 High High
Disease Link Frequency Relevance Heat
Leukemia 5 99.84 Very High Very High Very High
Cv General 3 Under Development 27 99.82 Very High Very High Very High
Hypertension 2 99.74 Very High Very High Very High
Thrombosis 10 99.46 Very High Very High Very High
Arrhythmia Under Development 1 99.22 Very High Very High Very High
Anaemia 2 99.06 Very High Very High Very High
Angina 3 98.98 Very High Very High Very High
Coronary Artery Disease 5 98.88 Very High Very High Very High
Coagulation Disorder 5 98.76 Very High Very High Very High
Atherosclerosis 3 98.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mor, Nal, D-Asp and PLG alone caused a significant decrease in food and fluid intake, urine volume and faeces weight and a significant increase in urinary osmolality being the osmolality of the Mor, D-Asp and PLG injected groups higher than 300 mOsmol/kg.
Negative_regulation (decrease) of PLG in urine associated with narcan and morphine
1) Confidence 0.40 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6694997 Disease Relevance 0 Pain Relevance 0.89
The plasma oxidized low-density lipoprotein (ox-LDL) level decreased significantly in the trial group (p < 0.01); the plasminogen activator inhibitor-1 (PAI-1) level decreased in both groups and it decreased more significantly in the trial group (p < 0.01).
Negative_regulation (decreased) of plasminogen in plasma
2) Confidence 0.38 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688814 Disease Relevance 0.50 Pain Relevance 0.36
Plasma fibrinogen was significantly higher (2.8 versus 2.3 g/l, P < 0.005) in patients than in controls, but there were no significant differences in the median plasma concentrations of euglobulin clot lysis time, fibrin plate lysis area, plasminogen, alpha-2-antiplasmin, tissue plasminogen activator activity, and antigen, tissue plasminogen activator inhibition and plasminogen activator inhibitor-1 antigen level.
Negative_regulation (inhibition) of plasminogen in plasma
3) Confidence 0.26 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7679035 Disease Relevance 0.48 Pain Relevance 0.39
Plasma fibrinogen was significantly higher (2.8 versus 2.3 g/l, P < 0.005) in patients than in controls, but there were no significant differences in the median plasma concentrations of euglobulin clot lysis time, fibrin plate lysis area, plasminogen, alpha-2-antiplasmin, tissue plasminogen activator activity, and antigen, tissue plasminogen activator inhibition and plasminogen activator inhibitor-1 antigen level.
Negative_regulation (inhibition) of plasminogen in plasma
4) Confidence 0.23 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7679035 Disease Relevance 0.48 Pain Relevance 0.39
Plasma fibrinogen was significantly higher (2.8 versus 2.3 g/l, P < 0.005) in patients than in controls, but there were no significant differences in the median plasma concentrations of euglobulin clot lysis time, fibrin plate lysis area, plasminogen, alpha-2-antiplasmin, tissue plasminogen activator activity, and antigen, tissue plasminogen activator inhibition and plasminogen activator inhibitor-1 antigen level.
Negative_regulation (inhibition) of plasminogen in plasma
5) Confidence 0.19 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 7679035 Disease Relevance 0.50 Pain Relevance 0.40
Tranexamic acid, a plasminogen inhibitor approved for the treatment of hemophilia, will also decrease flow by approximately 50%.
Negative_regulation (inhibitor) of plasminogen associated with coagulation disorder
6) Confidence 0.14 Published 2001 Journal Curr Womens Health Rep Section Abstract Doc Link 12112970 Disease Relevance 0.95 Pain Relevance 0.09
In healthy women taking oral contraception, there is an increase of fibrinolytic proteins: elevation of plasmin, factors VII, X, IX and a decrease of plasminogen activator inhibitor (PAI) [12-14].
Negative_regulation (decrease) of plasminogen
7) Confidence 0.13 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2918592 Disease Relevance 0.30 Pain Relevance 0.20
In comparison with control subjects, a lower level of released plasminogen activator was found in all CHD patients, being especially marked in those with unstable angina pectoris and acute myocardial infarction.
Negative_regulation (level) of plasminogen associated with angina, coronary artery disease and myocardial infarction
8) Confidence 0.08 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517077 Disease Relevance 0.81 Pain Relevance 0.19
[Unstable angina: tissue plasminogen activator, tissue plasminogen activator inhibitors, protein C and other factors of the blood fibrinolytic system].
Negative_regulation (inhibitors) of plasminogen in blood associated with angina
9) Confidence 0.06 Published 1991 Journal Kardiologiia Section Title Doc Link 1676768 Disease Relevance 0.27 Pain Relevance 0.42
The thrombus was consistently lysed by application of Thrombolysin (streptokinase and plasminogen) at the site of occlusion, 1 to 6 hours after thrombosis.
Negative_regulation (application) of plasminogen associated with thrombosis
10) Confidence 0.06 Published 1981 Journal Am. Heart J. Section Abstract Doc Link 7315719 Disease Relevance 0.73 Pain Relevance 0
Results similar to those with plasmin were obtained with conditioned media from macrophages and macrophage-like cell lines together with plasminogen activator, and the degradation of the PNS myelin proteins, Po and P1, under these conditions was inhibited by p-nitrophenylguanidinobenzoate, an inhibitor of plasmin and plasminogen activator.
Negative_regulation (inhibitor) of plasminogen in macrophages associated with peripheral nervous system
11) Confidence 0.06 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6167674 Disease Relevance 0.25 Pain Relevance 0.48
[Unstable angina: tissue plasminogen activator, tissue plasminogen activator inhibitors, protein C and other factors of the blood fibrinolytic system].
Negative_regulation (inhibitors) of plasminogen in blood associated with angina
12) Confidence 0.05 Published 1991 Journal Kardiologiia Section Title Doc Link 1676768 Disease Relevance 0.27 Pain Relevance 0.42
The study of the fibrinolytic system and the activity of interleukin 1 and 2 in 75 patients with various cardial manifestations of atherosclerosis (angina of effort, angina decubitus, arrhythmia, symptomatic hypertension) revealed a decrease in the activity of plasminogen--a blood activator--in patients with angina of effort, angina decubitus and cardiac arrhythmias.
Negative_regulation (decrease) of plasminogen in blood associated with angina, atherosclerosis, hypertension, arrhythmia under development and cva
13) Confidence 0.05 Published 1992 Journal Klin Med (Mosk) Section Abstract Doc Link 1507814 Disease Relevance 0.95 Pain Relevance 0.30
The induction chemotherapy included L-asparaginase which causes deficiencies of antithrombin, plasminogen, fibrinogen, and factors IX and XI.
Negative_regulation (deficiencies) of plasminogen
14) Confidence 0.04 Published 1980 Journal Cancer Section Abstract Doc Link 6932253 Disease Relevance 1.06 Pain Relevance 0.19
Subcutaneous injection of crude hemolymph and some chromatographic fractions of LA induce a decrease in fibrinogen, plasminogen and factor XIII.
Negative_regulation (decrease) of plasminogen in hemolymph
15) Confidence 0.03 Published 2000 Journal Biochimie Section Abstract Doc Link 11086223 Disease Relevance 0.44 Pain Relevance 0.07
In 14 patients in whom the decrease in fibrinogen and plasminogen levels was measured after the first and second infusions, this decrease was only 25% and 63%, respectively--only slightly higher than the 22% and 53% decreases measured in 63 patients who had only one rt-PA infusion.
Negative_regulation (decrease) of plasminogen
16) Confidence 0.03 Published 1990 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 2120309 Disease Relevance 0.65 Pain Relevance 0.19
Results similar to those with plasmin were obtained with conditioned media from macrophages and macrophage-like cell lines together with plasminogen activator, and the degradation of the PNS myelin proteins, Po and P1, under these conditions was inhibited by p-nitrophenylguanidinobenzoate, an inhibitor of plasmin and plasminogen activator.
Negative_regulation (inhibitor) of plasminogen in macrophage associated with peripheral nervous system
17) Confidence 0.02 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6167674 Disease Relevance 0.25 Pain Relevance 0.48
A decrease in plasminogen and alpha 2-antiplasmin suggested activation of the fibrinolytic system and a decrease in prekallikrein and kallikrein inhibition activity (C-1-esterase inhibitor) an activation of the kallikrein system.
Negative_regulation (decrease) of plasminogen
18) Confidence 0.02 Published 1986 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3739576 Disease Relevance 0.08 Pain Relevance 0.51
L-Asparaginase therapy for childhood acute lymphoblastic leukemia causes deficiencies of plasma hemostatic proteins, especially antithrombin, plasminogen, and fibrinogen.
Negative_regulation (deficiencies) of plasminogen in plasma associated with leukemia
19) Confidence 0.02 Published 1982 Journal J. Pediatr. Section Abstract Doc Link 6953221 Disease Relevance 1.35 Pain Relevance 0.33
The patients showed evidence of defective fibrinolysis--namely, significant prolongation of the euglobulin clot-lysis time, reduction in fibrin-plate lysis-area and plasminogen levels, and increase in levels of the fibrinolytic inhibitors, alpha 2 antiplasmin and alpha 2 macroglobulin.
Negative_regulation (reduction) of plasminogen
20) Confidence 0.01 Published 1984 Journal Lancet Section Abstract Doc Link 6150238 Disease Relevance 0.49 Pain Relevance 0.21

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