INT106103

Context Info Confidence 0.08 First Reported 2002 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 2.08 Pain Relevance 2.29

Anatomy Link Frequency medial 1 nerve 1 brain 1 nucleus 1 PRS (Homo sapiens)

Pain Link Frequency Relevance Heat amygdala 37 100.00 Dopamine 46 99.84 Spinal cord 7 99.84 agonist 25 98.92 Sciatic nerve 6 96.40 Kinase C 5 94.44 Dynorphin 11 94.08 Opioid 1 92.68 induced neuropathy 3 86.08 nud 1 85.96

Disease Link Frequency Relevance Heat Stress 10 100.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 10 99.92 Dyspepsia 1 85.96 Hyperalgesia 1 79.84 Hypersensitivity 1 70.08 Neuropathic Pain 3 68.20 Functional Bowel Disorder 1 66.28 Aids-related Complex 11 61.20 Decapitation 2 5.00 Hypogonadotropic Hypogonadism 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After CRD or PRS, Fos expression was increased in spinal cord section (S1), nucleus tractus solitarius (NTS), paraventricular nucleus (PVN) of the hypothalamus, and in the medial nucleus of the amygdala (MeA).

Positive_regulation (increased) of PRS in medial associated with stress, amygdala and spinal cord

1) Confidence 0.08 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309441 Disease Relevance 1.08 Pain Relevance 0.55

It is known that progesterone receptors (PRs) are required for the actions of P on GnRH secretion.

Positive_regulation (required) of PRs

2) Confidence 0.07 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.06 Pain Relevance 0.37

For example, PRs are expressed within the BST and CeA [15], [54] and are activated by DA or D1-like receptor agonists in vitro [14] and in adult female rat brain [55].

Positive_regulation (activated) of PRs in brain associated with dopamine, agonist and amygdala

3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.33

Except for that of NF-M in CC, the PRs of NF-L, NF-M and NF-H were also elevated in nerve tissues, which was consistent with the activation of protein kinases.

Positive_regulation (elevated) of PRs in nerve

4) Confidence 0.01 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.13 Pain Relevance 0.92

It is still unclear whether non-genomic effects are mediated by membrane receptors distinct from the nuclear receptors, or additionally involve activation of classical ERs or PRs located outside the nucleus [4-9].

Positive_regulation (activation) of PRs in nucleus

5) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.12

General Comments

This test has worked.