INT106103

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.08
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medial 1
nerve 1
brain 1
nucleus 1
PRS (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 37 100.00 Very High Very High Very High
Dopamine 46 99.84 Very High Very High Very High
Spinal cord 7 99.84 Very High Very High Very High
agonist 25 98.92 Very High Very High Very High
Sciatic nerve 6 96.40 Very High Very High Very High
Kinase C 5 94.44 High High
Dynorphin 11 94.08 High High
Opioid 1 92.68 High High
induced neuropathy 3 86.08 High High
nud 1 85.96 High High
Disease Link Frequency Relevance Heat
Stress 10 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 99.92 Very High Very High Very High
Dyspepsia 1 85.96 High High
Hyperalgesia 1 79.84 Quite High
Hypersensitivity 1 70.08 Quite High
Neuropathic Pain 3 68.20 Quite High
Functional Bowel Disorder 1 66.28 Quite High
Aids-related Complex 11 61.20 Quite High
Decapitation 2 5.00 Very Low Very Low Very Low
Hypogonadotropic Hypogonadism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After CRD or PRS, Fos expression was increased in spinal cord section (S1), nucleus tractus solitarius (NTS), paraventricular nucleus (PVN) of the hypothalamus, and in the medial nucleus of the amygdala (MeA).
Positive_regulation (increased) of PRS in medial associated with stress, amygdala and spinal cord
1) Confidence 0.08 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309441 Disease Relevance 1.08 Pain Relevance 0.55
It is known that progesterone receptors (PRs) are required for the actions of P on GnRH secretion.
Positive_regulation (required) of PRs
2) Confidence 0.07 Published 2002 Journal Endocrinology Section Abstract Doc Link 12399433 Disease Relevance 0.06 Pain Relevance 0.37
For example, PRs are expressed within the BST and CeA [15], [54] and are activated by DA or D1-like receptor agonists in vitro [14] and in adult female rat brain [55].
Positive_regulation (activated) of PRs in brain associated with dopamine, agonist and amygdala
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.33
Except for that of NF-M in CC, the PRs of NF-L, NF-M and NF-H were also elevated in nerve tissues, which was consistent with the activation of protein kinases.
Positive_regulation (elevated) of PRs in nerve
4) Confidence 0.01 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.13 Pain Relevance 0.92
It is still unclear whether non-genomic effects are mediated by membrane receptors distinct from the nuclear receptors, or additionally involve activation of classical ERs or PRs located outside the nucleus [4-9].
Positive_regulation (activation) of PRs in nucleus
5) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.12

General Comments

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