INT106106

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.66
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) Golgi apparatus (Pick1) enzyme binding (Pick1)
protein complex (Pick1) cytoplasm (Pick1) protein targeting (Pick1)
Pick1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 97.48 Very High Very High Very High
ASIC 3 94.32 High High
GABAergic 39 91.28 High High
Kinase C 5 81.88 Quite High
nMDA receptor 9 69.28 Quite High
tetrodotoxin 9 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 97.48 Very High Very High Very High
Toxicity 1 97.32 Very High Very High Very High
Schizophrenia 1 97.12 Very High Very High Very High
Cancer 1 96.52 Very High Very High Very High
Disease 4 95.92 Very High Very High Very High
Hypoxia 144 59.60 Quite High
Ganglion Cysts 11 14.96 Low Low
Vibrio Infection 1 6.16 Low Low
Stress 5 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To better understand the physiological function of PICK1, we expressed the recombinant PICK1 and its truncated mutants in E.coli, and measured their zinc binding properties by fluorescence and competition assay.
Gene_expression (expressed) of PICK1
1) Confidence 0.70 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18429931 Disease Relevance 0.39 Pain Relevance 0.10
Long-term overexpression of PICK1 (or the inactive PDZ-domain mutant) was attempted but resulted in toxicity; SPT analysis after 24 h revealed no significant effect of PICK1 on ?
Gene_expression (overexpression) of PICK1 associated with toxicity
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0.10 Pain Relevance 0.11
The OAG-induced increase in ASIC2a current amplitude did not involve any change in the unitary conductance of the ASIC2a channel, whether co-expressed with PICK1 or not.
Neg (not) Spec (whether) Gene_expression (co-expressed) of PICK1
3) Confidence 0.51 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12399460 Disease Relevance 0.06 Pain Relevance 0.35
Ten were not represented (AKAP9, BAIAP1, CASR, DLG2, EPHB4, GRIN3B, GUCY2C, GUCY2D, NPR2, and PRKCABP).
Neg (not) Gene_expression (represented) of PRKCABP
4) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.11 Pain Relevance 0.12

General Comments

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