INT106127

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 7.12
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CASR) signal transducer activity (CASR)
CASR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
agonist 3 99.86 Very High Very High Very High
Chronic pancreatitis 78 95.12 Very High Very High Very High
headache 3 94.60 High High
Arthritis 1 93.20 High High
Pain 3 39.68 Quite Low
abdominal pain 1 38.08 Quite Low
Glutamate 11 26.32 Quite Low
chemokine 7 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 105 100.00 Very High Very High Very High
Iron Overload 17 100.00 Very High Very High Very High
Pancreatitis 138 99.40 Very High Very High Very High
Diabetes Insipidus 1 99.08 Very High Very High Very High
Headache 3 94.60 High High
Chondrodysplasia 1 93.80 High High
Arthritis 1 93.20 High High
Reprotox - General 2 1 92.64 High High
Diabetes Mellitus 1 92.08 High High
Coronary Heart Disease 1 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While a heterozygous inactivating CASR mutation leads to FHH, homozygous mutations result in severe neonatal pHPT.
Negative_regulation (inactivating) of CASR associated with hypercalcemia
1) Confidence 0.43 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.49 Pain Relevance 0.07
Subsequently they identified three different CASR mutations, suggesting that they may represent distinct FHH variants with pancreatitis.
Spec (may) Negative_regulation (represent) of FHH associated with pancreatitis and hypercalcemia
2) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.31 Pain Relevance 0.22
EST matches for CASR, PTHR1 and AVPR2 orthologs can be recovered in Ciona [Additional data file 2: Sheet 2].
Negative_regulation (recovered) of CASR
3) Confidence 0.28 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.58 Pain Relevance 0
HHC can be treated or prevented by regular phlebotomy treatments.
Negative_regulation (prevented) of HHC associated with iron overload
4) Confidence 0.26 Published 2002 Journal Best Pract Res Clin Haematol Section Abstract Doc Link 12401310 Disease Relevance 1.32 Pain Relevance 0.05
FHH is usually associated with heterozygous inactivating mutations of the CaR gene, whereas NSHPT is usually due to homozygous inactivation of the CaR gene.
Negative_regulation (inactivation) of CaR associated with hypercalcemia
5) Confidence 0.19 Published 2004 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 15579740 Disease Relevance 0.78 Pain Relevance 0.07
This study reinforces the fact that patients with homozygous inactivation of the CaR gene may present with severe hypercalcemia in different phases of life.
Negative_regulation (inactivation) of CaR associated with hypercalcemia
6) Confidence 0.19 Published 2004 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 15579740 Disease Relevance 0.57 Pain Relevance 0.07
In the present study its involvement in the effects of calcium was examined by using a CaR agonist and a CaR antagonist.
Negative_regulation (antagonist) of CaR associated with antagonist and agonist
7) Confidence 0.16 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0.23 Pain Relevance 0.10
In this study, we report a novel inactivating mutation of the CaR gene, identified in a 9-yr-old Brazilian girl who was found to be severely hypercalcemic during investigation of a 6-month history of headaches and vomits.
Negative_regulation (inactivating) of CaR associated with headache
8) Confidence 0.14 Published 2004 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 15579740 Disease Relevance 0.83 Pain Relevance 0.09

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