INT106142

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.71
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 4
lamina 2
ventral 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 99.96 Very High Very High Very High
Spinal cord 31 99.90 Very High Very High Very High
electroacupuncture 9 99.64 Very High Very High Very High
intrathecal 10 95.84 Very High Very High Very High
analgesia 4 94.24 High High
Pain 15 77.92 Quite High
Analgesic 4 75.88 Quite High
antagonist 21 55.64 Quite High
Serotonin 18 50.00 Quite Low
ascending facilitation 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nociception 19 95.28 Very High Very High Very High
Hypersensitivity 2 92.64 High High
Aging 1 89.76 High High
Post Operative Pain 5 30.00 Quite Low
Pain 13 24.40 Low Low
Hyperalgesia 17 9.52 Low Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rats were killed 2 h after the formalin injection, and the lumbar spinal cord was stained for c-fos or the phosphorylated NMDA receptor immunohistochemically.
Positive_regulation (stained) of Phosphorylation (phosphorylated) of c-fos in spinal cord associated with nmda receptor and spinal cord
1) Confidence 0.49 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12401615 Disease Relevance 0.25 Pain Relevance 0.45
At 60 min after the termination of EA stimulation, the levels of c-fos, serine phosphorylation of NR1 and NR2B by Western analysis had increased in the L(4-5) segments of the spinal cord after EA treatment.
Positive_regulation (levels) of Phosphorylation (phosphorylation) of c-fos in spinal cord associated with electroacupuncture and spinal cord
2) Confidence 0.49 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355647 Disease Relevance 0 Pain Relevance 0.79
Immunohistochemical analysis found that the brain response to formalin injection was also more sensitive in middle-aged rats than young rats; a significant increase in the number of c-Fos immunoreactive cells was found in the ventral portion of the lateral septum of middle-aged rats injected with formalin compared to young and middle-aged rats injected with saline, irrespective of estrous cyclicity.
Positive_regulation (increase) of Phosphorylation (number) of c-Fos in ventral
3) Confidence 0.49 Published 2010 Journal Physiol. Behav. Section Abstract Doc Link 20156467 Disease Relevance 0.41 Pain Relevance 0.08
The incision-induced increase in the number of Fos-LI neurons in the ipsilateral lamina V of rats from the group ASI was less intense after methysergide (30 ?
Positive_regulation (increase) of Phosphorylation (number) of Fos in lamina
4) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2860347 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

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