INT106153

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Context Info
Confidence 0.04
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.33
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HJURP) chromosome segregation (HJURP) histone binding (HJURP)
cytoplasm (HJURP) chromosome (HJURP) nucleolus (HJURP)
Anatomy Link Frequency
embryos 1
neurons 1
femur 1
neutrophil 1
HJURP (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 99.80 Very High Very High Very High
Neuropathic pain 8 99.00 Very High Very High Very High
Spinal nerve ligature 4 91.32 High High
Pain 4 90.96 High High
Cancer pain 2 90.44 High High
spinal dorsal horn 2 89.76 High High
Hyperalgesia 2 83.68 Quite High
Enkephalin 2 81.84 Quite High
Inflammation 2 69.96 Quite High
headache 1 56.96 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 8 99.00 Very High Very High Very High
Herpes Simplex Virus 2 98.84 Very High Very High Very High
Targeted Disruption 3 97.58 Very High Very High Very High
Sarcoma 1 95.78 Very High Very High Very High
Pain 4 90.96 High High
Cancer Pain 2 90.44 High High
Bone Cancer 2 90.24 High High
Nociception 1 89.20 High High
Stroke 9 86.56 High High
Hyperalgesia 2 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replication-defective herpes simplex virus vector expressing human proenkephalin (vector SHPE) or a lacZ-expressing control vector (vector SHZ).
Gene_expression (expressing) of lacZ-expressing in femur associated with sarcoma and herpes simplex virus
1) Confidence 0.04 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 12402268 Disease Relevance 0.79 Pain Relevance 0.42
To test this model more quantitatively, we injected mitfa:egfp transgenic embryos [37] with either tfap2a MO or both tfap2a MO and tfap2e MO, dissociated them at 29 hpf, sorted and collected GFP-expressing cells, and measured the levels of various transcripts by quantitative RT-PCR (Figure 5N).
Gene_expression (-) of expressing in embryos associated with targeted disruption
2) Confidence 0.01 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2940735 Disease Relevance 0.10 Pain Relevance 0
Injection of GDNF-expressing viral vectors induced a significant reduction of ATF-3 up-regulation and IB4 down-regulation in damaged DRG neurons.
Gene_expression (expressing) of GDNF-expressing in neurons
3) Confidence 0.00 Published 2006 Journal Mol. Ther. Section Abstract Doc Link 16504588 Disease Relevance 0.39 Pain Relevance 0.67
We chose to administer GDNF-expressing vectors because of the known beneficial effect of this trophic factor in alleviation of neuropathic pain in adult rodents.
Gene_expression (expressing) of GDNF-expressing associated with neuropathic pain
4) Confidence 0.00 Published 2006 Journal Mol. Ther. Section Abstract Doc Link 16504588 Disease Relevance 0.35 Pain Relevance 0.46
CXCL5 is one of the ELR-expressing CXC chemokines and is a potent neutrophil attractant and activator.
Gene_expression (expressing) of ELR-expressing in neutrophil associated with chemokine
5) Confidence 0.00 Published 2006 Journal Folia Morphol. (Warsz) Section Abstract Doc Link 16783727 Disease Relevance 0.70 Pain Relevance 0.31

General Comments

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