INT106175

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 37
Total Number 39
Disease Relevance 13.89
Pain Relevance 22.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
spinal cord 6
Spinal 6
dorsal horn 4
hippocampus 4
brain structures 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 53 100.00 Very High Very High Very High
addiction 30 100.00 Very High Very High Very High
spinal dorsal horn 29 100.00 Very High Very High Very High
intrathecal 14 100.00 Very High Very High Very High
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Morphine 90 99.98 Very High Very High Very High
bDMF 72 99.96 Very High Very High Very High
sSRI 8 99.88 Very High Very High Very High
qutenza 70 99.84 Very High Very High Very High
antidepressant 69 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 224 99.98 Very High Very High Very High
Nociception 120 99.98 Very High Very High Very High
Injury 30 99.76 Very High Very High Very High
Frailty 15 99.56 Very High Very High Very High
Hyperalgesia 25 99.32 Very High Very High Very High
INFLAMMATION 50 99.26 Very High Very High Very High
Cognitive Disorder 57 98.94 Very High Very High Very High
Neuropathic Pain 12 97.90 Very High Very High Very High
Inflammatory Pain 9 97.72 Very High Very High Very High
Neuroblastoma 1 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment of fluoxetine, a selective serotonin reuptake inhibitor, can upregulate CREB activation in the hippocampus.
Positive_regulation (upregulate) of Positive_regulation (activation) of CREB in hippocampus associated with hippocampus, ssri and fluoxetine
1) Confidence 0.70 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16887358 Disease Relevance 1.00 Pain Relevance 0.75
Furthermore, they are consistent with in vivo evidence suggesting that increased CREB activation in portions of the striatum (e.g. the NAc) is related to dysphoric states associated with drug withdrawal.
Positive_regulation (increased) of Positive_regulation (activation) of CREB in striatum associated with nucleus accumbens and withdrawal
2) Confidence 0.69 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.06 Pain Relevance 1.25
Enhanced phosphorylation of CREB through the activation of glutamate receptors and the above kinase cascades during central sensitization suggest a connection between CREB phosphorylation and the molecular mechanisms governing stimuli-induced CREB activation by protein kinase pathways.
Positive_regulation (induced) of Positive_regulation (activation) of CREB associated with central sensitization and glutamate receptor
3) Confidence 0.68 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.42 Pain Relevance 0.60
Multiple kinase pathways mediate the early sciatic ligation-associated activation of CREB in the rat spinal dorsal horn.
Positive_regulation (mediate) of Positive_regulation (activation) of CREB in spinal associated with spinal dorsal horn
4) Confidence 0.63 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15882794 Disease Relevance 0.19 Pain Relevance 0.45
The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB.
Positive_regulation (inactivated) of Positive_regulation (activation) of CREB
5) Confidence 0.50 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.08 Pain Relevance 0.30
We analysed the temporal profile of intracellular changes induced by antidepressants, by measuring activation of major CREB-regulating signalling cascades and activation (Ser133 phosphorylation) of CREB.
Positive_regulation (activation) of Positive_regulation (activation) of CREB associated with antidepressant
6) Confidence 0.50 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19400982 Disease Relevance 0.05 Pain Relevance 0.27
Early induction of CREB activation and CREB-regulating signalling by antidepressants.
Positive_regulation (induction) of Positive_regulation (induction) of CREB associated with antidepressant
7) Confidence 0.50 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Title Doc Link 19400982 Disease Relevance 0.05 Pain Relevance 0.26
Spinal activation of the cAMP induced gene transcription through the activation of protein kinase A and cAMP response element-binding protein (CREB).
Positive_regulation (induced) of Positive_regulation (activation) of CREB in Spinal associated with intrathecal
8) Confidence 0.50 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 18042889 Disease Relevance 0.27 Pain Relevance 0.62
Spinal activation of the cAMP induced gene transcription through the activation of protein kinase A and cAMP response element-binding protein (CREB).
Positive_regulation (induced) of Positive_regulation (activation) of cAMP response element-binding protein in Spinal associated with intrathecal
9) Confidence 0.50 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 18042889 Disease Relevance 0.27 Pain Relevance 0.62
In addition, the current results replicated our previous finding that activated CREB is upregulated following SCI, however, only in SCI rats that developed CNP.
Positive_regulation (upregulated) of Positive_regulation (activated) of CREB associated with frailty
10) Confidence 0.50 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16478624 Disease Relevance 0.97 Pain Relevance 0.48
These kinases play an important role in the subsequent activation or phosphorylation of the transcription factor, CREB.
Positive_regulation (role) of Positive_regulation (activation) of CREB
11) Confidence 0.49 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0 Pain Relevance 0.14
These data provided further support for the notion that at least some of the injury-associated activation of CREB in the spinal dorsal horn may be dependent upon BDNF-mediated activation of Trk receptors.
Spec (may) Positive_regulation (dependent) of Positive_regulation (activation) of CREB in dorsal horn associated with spinal dorsal horn and injury
12) Confidence 0.48 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15135945 Disease Relevance 0.25 Pain Relevance 0.29
Our results suggested that activation of ERK/CREB pathway in spinal dorsal neurons is necessary for induction and maintenance of long-term potentiation of the C-fiber evoked field potentials.
Positive_regulation (necessary) of Positive_regulation (activation) of CREB in neurons associated with c fibre and long-term potentiation
13) Confidence 0.47 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16902997 Disease Relevance 0.06 Pain Relevance 0.99
Early induction of CREB activation and CREB-regulating signalling by antidepressants.
Positive_regulation (induction) of Positive_regulation (activation) of CREB-regulating associated with antidepressant
14) Confidence 0.47 Published 2009 Journal Int. J. Neuropsychopharmacol. Section Title Doc Link 19400982 Disease Relevance 0.05 Pain Relevance 0.29
The increased CREB activation associated with thermal hyperalgesia was accompanied by significant decreases in the content of both calcineurin Aalpha and Abeta.
Positive_regulation (increased) of Positive_regulation (activation) of CREB associated with thermal hyperalgesia and abeta
15) Confidence 0.46 Published 2002 Journal Pain Section Abstract Doc Link 12406525 Disease Relevance 0.95 Pain Relevance 1.03
In conclusion, our results suggest that inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain.
Positive_regulation (leading) of Positive_regulation (up-regulation) of CREB associated with inflammation, ipn and calcitonin gene-related peptide
16) Confidence 0.45 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.03 Pain Relevance 1.13
In animals exhibiting thermal hyperalgesia as a behavioral sign of neuropathic pain 7 days after loose ligation of the sciatic nerve (chronic constriction injury), there was a significant increase in the content of phosphorylated (activated) CREB (pCREB).
Positive_regulation (increase) of Positive_regulation (activated) of pCREB in sciatic nerve associated with eae, thermal hyperalgesia, injury, neuropathic pain and sciatic nerve
17) Confidence 0.44 Published 2002 Journal Pain Section Abstract Doc Link 12406525 Disease Relevance 0.94 Pain Relevance 0.99
Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.
Positive_regulation (fluoxetine-induced) of Positive_regulation (activation) of CREB associated with fluoxetine
18) Confidence 0.43 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.17
We previously reported that increasing CREB activity in glutamatergic neurons enhances synaptic plasticity and neuronal excitability.
Positive_regulation (enhances) of Positive_regulation (increasing) of CREB in neuronal associated with neuronal excitability
19) Confidence 0.41 Published 2009 Journal Hippocampus Section Abstract Doc Link 19004015 Disease Relevance 0 Pain Relevance 0.11
The increase in p-CREB induced by capsaicin injection was partially blocked by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, administered through a microdialysis fiber placed across the spinal cord.
Positive_regulation (induced) of Positive_regulation (increase) of p-CREB in spinal cord associated with qutenza and spinal cord
20) Confidence 0.41 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.88

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