INT106189

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2002
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 12.40
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12a) extracellular region (Il12a) cytoplasm (Il12a)
Anatomy Link Frequency
leukocyte 1
dendritic cells 1
T-cell 1
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 318 100.00 Very High Very High Very High
chemokine 84 100.00 Very High Very High Very High
Cannabinoid 68 99.84 Very High Very High Very High
agonist 88 99.04 Very High Very High Very High
psoriasis 56 97.48 Very High Very High Very High
Sciatic nerve 1 96.16 Very High Very High Very High
diclofenac 1 94.12 High High
Inflammation 200 93.64 High High
aspirin 2 92.84 High High
Neurotransmitter 6 91.28 High High
Disease Link Frequency Relevance Heat
Adhesions 11 100.00 Very High Very High Very High
Infection 379 99.76 Very High Very High Very High
Multiple Sclerosis 191 99.76 Very High Very High Very High
Targeted Disruption 29 99.64 Very High Very High Very High
Mycobacterial Infection 149 99.56 Very High Very High Very High
Chlamydia Infection 68 99.40 Very High Very High Very High
Syndrome 15 98.04 Very High Very High Very High
Helminth Infection 39 97.60 Very High Very High Very High
Psoriasis 69 97.48 Very High Very High Very High
Disease 143 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the IL-12 deficiency appeared not to affect P0 peptide 180-199-specific T-cell proliferation.
Neg (not) Regulation (affect) of IL-12 in T-cell
1) Confidence 0.44 Published 2002 Journal Brain Pathol. Section Abstract Doc Link 12408228 Disease Relevance 0.84 Pain Relevance 0.63
Six hours after the challenge, the local exudates were collected and subjected for total leukocyte infiltration count and IL-12 assessment.
Regulation (subjected) of IL-12 in leukocyte
2) Confidence 0.43 Published 2006 Journal Egypt J Immunol Section Abstract Doc Link 18689271 Disease Relevance 0.78 Pain Relevance 0.36
and Theiler’s virus were used to study the effects of cannabinoids on the regulation of IL-12 and IL-23 mRNA and protein IL-12 p40.
Regulation (regulation) of IL-12 associated with cannabinoid
3) Confidence 0.24 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.75 Pain Relevance 0.91
A recent report indicated a profilin-like molecule from the protozoan parasite Toxoplasma gondii interacts with TLR11 generating a potent interleukin-12 (IL-12) response in murine dendritic cells that is dependent on myeloid differentiation factor 88 [53].
Regulation (dependent) of IL-12 in dendritic cells
4) Confidence 0.21 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2631477 Disease Relevance 0.24 Pain Relevance 0.03
Of the 17 subjects who received the IL-12/23 monoclonal antibody, 13 (76%) achieved PASI 75, compared with no placebo subjects. mRNA expression of IL-12, IL-23, IL-8, IL-18, and IFN-?
Regulation (received) of IL-12
5) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.28 Pain Relevance 0.10
and Theiler’s virus were used to study the effects of cannabinoids on the regulation of IL-12 and IL-23 mRNA and protein IL-12 p40.
Regulation (regulation) of IL-12 associated with cannabinoid
6) Confidence 0.15 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.77 Pain Relevance 0.94
To further assess the systemic immune response IL-12, IFN-?
Regulation (response) of IL-12
7) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2715133 Disease Relevance 0.08 Pain Relevance 0.04
Changes in splenic weight and serum IL-12 levels were evaluated after treatment with AS Bcl-2 or synthetic CpG AS Bcl-2 ODNs.


Regulation (Changes) of IL-12
8) Confidence 0.11 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.40 Pain Relevance 0.06
Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida.
Regulation (role) of IL-35 associated with cytokine
9) Confidence 0.11 Published 2011 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2963117 Disease Relevance 0.55 Pain Relevance 0.18
Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida.
Regulation (role) of IL-12 associated with cytokine
10) Confidence 0.11 Published 2011 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2963117 Disease Relevance 0.55 Pain Relevance 0.18
Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida.
Regulation (role) of IL-12 associated with cytokine
11) Confidence 0.11 Published 2011 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2963117 Disease Relevance 0.54 Pain Relevance 0.18
Ongoing clinical trials with agents that target IL-12 likewise are showing encouraging efficacy in the treatment of psoriasis and Crohn’s disease [10, 11], and the list of anti-cytokine therapies entering clinical trials grows regularly [6].
Regulation (target) of IL-12 associated with psoriasis, disease and cytokine
12) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 1.38 Pain Relevance 0.74
and IL-12, a typical Th1 response.
Regulation (response) of IL-12
13) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2553283 Disease Relevance 0.98 Pain Relevance 0
Marked alterations in expressio n of immunomodulator mRNA, including C-C chemokine RANTES, C-C chemokine receptors CCR1, CCR3 and CCR5, adhesion molecules PECAM-1, ICAM-1, and VCAM-1, cytokines IF N-gamma, TNF-alpha, IL-12, IL-4, and iNOS were observed to be up-regulated, while growth factors, GDF-2 and TGF-beta precursor, were down-regulated (Table 2, P < 0.05) at peak parasitaemia.


Regulation (alterations) of IL-12 associated with chemokine, adhesions and cytokine
14) Confidence 0.05 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.15 Pain Relevance 0.23
The use of some cytokines, such as IL-2, IL-7, IL-12, or IFN-?
Regulation (use) of IL-12 associated with cytokine
15) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.13 Pain Relevance 0.05
Indeed, studies of chlamydial infection in knockout mice support the importance of class II MHC, CD4, IL-12, IFN-?
Regulation (importance) of IL-12 associated with targeted disruption and chlamydia infection
16) Confidence 0.04 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.72 Pain Relevance 0.19
agonists may modulate the development of EAE in part by modulating IL-12 family
Regulation (modulating) of IL-12 associated with multiple sclerosis and agonist
17) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.53 Pain Relevance 0.27
The induction of T helper 1 (Th1) responses during M.tuberculosis infection is largely dependent on IL-12 [12].
Regulation (dependent) of IL-12 associated with mycobacterial infection and infection
18) Confidence 0.03 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.74 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox