INT106199

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 13.68
Pain Relevance 9.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1) extracellular space (Adcyap1) extracellular region (Adcyap1)
Anatomy Link Frequency
pituitary 4
neurons 3
urinary bladder 2
Liver 2
nervous system 2
Adcyap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 130 100.00 Very High Very High Very High
adenocard 17 100.00 Very High Very High Very High
Glutamate 124 99.88 Very High Very High Very High
Morphine 8 99.84 Very High Very High Very High
cytokine 31 99.62 Very High Very High Very High
analgesia 3 99.48 Very High Very High Very High
Central nervous system 186 99.32 Very High Very High Very High
Chronic pancreatitis 4 99.28 Very High Very High Very High
addiction 7 99.04 Very High Very High Very High
Inflammatory response 8 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 6 99.84 Very High Very High Very High
INFLAMMATION 175 99.72 Very High Very High Very High
Pancreatitis 24 99.28 Very High Very High Very High
Nervous System Injury 6 99.04 Very High Very High Very High
Cystitis 6 98.48 Very High Very High Very High
Fatigue 88 98.04 Very High Very High Very High
Injury 36 97.36 Very High Very High Very High
Cv Unclassified Under Development 9 97.36 Very High Very High Very High
Neuropathic Pain 16 95.52 Very High Very High Very High
Multiple Sclerosis 224 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Development of human chronic pancreatitis is associated with intrapancreatic accumulation of pituitary adenylate cyclase-activating polypeptide (PACAP) accompanied with an altered inflammatory response (Michalski et al., Am J Physiol Gastrointest Liver Physiol. 2008;294:G50-G57).
Positive_regulation (accumulation) of PACAP in Liver associated with inflammatory response and chronic pancreatitis
1) Confidence 0.68 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.67 Pain Relevance 0.18
Development of human chronic pancreatitis is associated with intrapancreatic accumulation of pituitary adenylate cyclase-activating polypeptide (PACAP) accompanied with an altered inflammatory response (Michalski et al., Am J Physiol Gastrointest Liver Physiol. 2008;294:G50-G57).
Positive_regulation (accumulation) of pituitary adenylate cyclase-activating polypeptide in Liver associated with inflammatory response and chronic pancreatitis
2) Confidence 0.68 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.67 Pain Relevance 0.18
PACAP immunoreactivity (IR) is increased in micturition reflex pathways following cystitis.
Positive_regulation (increased) of PACAP associated with cystitis and overactive bladder
3) Confidence 0.61 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16888187 Disease Relevance 0.35 Pain Relevance 0.13
PACAP enhances mouse urinary bladder contractility and is upregulated in micturition reflex pathways after cystitis.
Positive_regulation (upregulated) of PACAP in urinary bladder associated with cystitis and overactive bladder
4) Confidence 0.61 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 16888187 Disease Relevance 0.37 Pain Relevance 0.12
Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.
Positive_regulation (pancreatic) of PACAP in pituitary associated with pancreatitis and cytokine
5) Confidence 0.49 Published 2009 Journal J. Pharmacol. Sci. Section Title Doc Link 19672038 Disease Relevance 0.79 Pain Relevance 0.26
However, varieties and inconsistencies among these results have complicated our understanding of the role of PACAP: slice cultures analyses suggest that PACAP is both an inducer and a modulator of phase shifts, because PACAP at nanomolar concentrations is alone sufficient to induce phase shifts [17], yet higher concentrations of PACAP enhance or repress glutamate-induced phase delay or advance, respectively [18].
Positive_regulation (sufficient) of PACAP associated with glutamate
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.15 Pain Relevance 0.13
However, varieties and inconsistencies among these results have complicated our understanding of the role of PACAP: slice cultures analyses suggest that PACAP is both an inducer and a modulator of phase shifts, because PACAP at nanomolar concentrations is alone sufficient to induce phase shifts [17], yet higher concentrations of PACAP enhance or repress glutamate-induced phase delay or advance, respectively [18].
Positive_regulation (inducer) of PACAP associated with glutamate
7) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823792 Disease Relevance 0.16 Pain Relevance 0.13
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and implicated in neurotransmission, neural plasticity, and neurotrophic actions.
Positive_regulation (distributed) of PACAP in nervous system associated with neuropeptide
8) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.66 Pain Relevance 0.66
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and implicated in neurotransmission, neural plasticity, and neurotrophic actions.
Positive_regulation (distributed) of neuropeptide pituitary adenylate cyclase-activating polypeptide in nervous system associated with neuropeptide
9) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.66 Pain Relevance 0.67
PACAP enhances mouse urinary bladder contractility and is upregulated in micturition reflex pathways after cystitis.
Positive_regulation (upregulated) of PACAP in urinary bladder associated with cystitis and overactive bladder
10) Confidence 0.44 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 16888187 Disease Relevance 0.37 Pain Relevance 0.12
Theophylline (1 mg/kg, i.p.) pretreatment significantly enhanced the effect of PACAP on morphine analgesia but the effects of PACAP on tolerance and withdrawal were unaffected upon theophylline administration.
Positive_regulation (enhanced) of PACAP associated with tolerance, withdrawal, analgesia and morphine
11) Confidence 0.44 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 12409215 Disease Relevance 0.16 Pain Relevance 1.71
Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.
Positive_regulation (pancreatic) of pituitary adenylate cyclase-activating polypeptide in pituitary associated with pancreatitis and cytokine
12) Confidence 0.43 Published 2009 Journal J. Pharmacol. Sci. Section Title Doc Link 19672038 Disease Relevance 0.79 Pain Relevance 0.26
Concomitant with the increase in PACAP immunoreactivity after nerve injury, NADPH-dependent nitric oxide synthase (NOS) activity visualized by NADPH diaphorase histochemistry markedly increased in the superficial layer of the spinal cord of wild-type mice, which was not observed in PACAP-/- mice.
Positive_regulation (increase) of PACAP in nerve associated with nervous system injury and spinal cord
13) Confidence 0.41 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.82 Pain Relevance 0.94
A larger percentage of genes up-regulated at 24 hr than at 1 hr required endogenous PACAP, suggesting a more prominent role for PACAP in later response to injury than in the initial response.
Positive_regulation (required) of PACAP associated with injury
14) Confidence 0.40 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 17027094 Disease Relevance 1.08 Pain Relevance 0.24
In the present study, we examined the concentration dependence of PACAP evoked changes in Ca2+ transients and PACAP enhancement of AMPA currents.
Positive_regulation (enhancement) of PACAP associated with addiction
15) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.12
In the next set of experiments, we wanted to determine if this e ffect of PACAP is mediated by PAC1 receptors and a regulation of the adenylyl cyclase (AC) signalling cascade (Fig. 2B).
Positive_regulation (mediated) of PACAP
16) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.11
PACAP-mediated increases in cytosolic Ca2+ have been observed previously in cultured rat SCN neurons and have been found due to the release of Ca2+ from intracellular stores [16,34].
Positive_regulation (increases) of PACAP in neurons
17) Confidence 0.34 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.05 Pain Relevance 0.10
PACAP and VIP, as potent activators of adenylate cyclase (AC), have a key role in cyclic adenosine monophosphate (cAMP) production affecting BBB/BSB function along with regulatory T cell (Treg) and other immune functions.
Positive_regulation (activators) of PACAP in regulatory T cell associated with adenocard
18) Confidence 0.32 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.00 Pain Relevance 0.23
Many regulatory and antiinflammatory functions of PACAP and VIP are dependent on the Th2-directed cytokines93 eg, interleukin-10 (IL-10) and IL-4 and these could be compromised in PACAP/VIP failure.
Positive_regulation (dependent) of PACAP associated with inflammation
19) Confidence 0.32 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.79 Pain Relevance 0.10
PACAP and VIP, as potent activators of adenylate cyclase (AC), have a key role in cyclic adenosine monophosphate (cAMP) production affecting regulatory T cell (Treg) and other immune functions.
Positive_regulation (activators) of PACAP in Treg associated with adenocard
20) Confidence 0.32 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2695238 Disease Relevance 0.77 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox