INT106200

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 16.70
Pain Relevance 9.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 6
neurons 3
sensory neurons 1
macrophages 1
fibroblasts 1
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 501 100.00 Very High Very High Very High
fibrosis 11 99.16 Very High Very High Very High
Lasting pain 19 98.64 Very High Very High Very High
Chronic pancreatitis 6 98.20 Very High Very High Very High
Paracetamol 56 98.04 Very High Very High Very High
agonist 8 97.40 Very High Very High Very High
dorsal root ganglion 207 97.00 Very High Very High Very High
allodynia 10 97.00 Very High Very High Very High
Inflammation 314 96.12 Very High Very High Very High
peripheral neuropathy 21 93.40 High High
Disease Link Frequency Relevance Heat
Status Epilepticus 318 99.72 Very High Very High Very High
Renal Disease 6 99.42 Very High Very High Very High
Fibrosis 11 99.16 Very High Very High Very High
Diabetes Mellitus 97 99.04 Very High Very High Very High
Pain 88 98.64 Very High Very High Very High
Nociception 61 98.60 Very High Very High Very High
Pancreatitis 6 98.20 Very High Very High Very High
Injury 296 98.16 Very High Very High Very High
Nervous System Injury 148 97.76 Very High Very High Very High
Endometriosis (extended) 4 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue sections were analyzed for the presence of IB4-binding neurons and either MCP-1, IP-10 or CCR2.
MCP-1 Binding (binding) of in neurons
1) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0 Pain Relevance 0
As for immune system activation and recruitment, MCP-1 is associated with both resident spinal microglia and infiltrating macrophages [42] and CCR2 null mice do not develop microglial activation [43].
MCP-1 Binding (associated) of in microglia
2) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2799401 Disease Relevance 1.73 Pain Relevance 1.21
Furthermore, we examined the relation of monocyte chemoattractant protein-1 (MCP-1) to the development of pancreatic fibrosis in this model.
monocyte chemoattractant protein-1 Spec (examined) Binding (relation) of in monocyte associated with fibrosis
3) Confidence 0.37 Published 2002 Journal Pancreas Section Abstract Doc Link 12409843 Disease Relevance 0.55 Pain Relevance 0.41
Furthermore, we examined the relation of monocyte chemoattractant protein-1 (MCP-1) to the development of pancreatic fibrosis in this model.
MCP-1 Spec (examined) Binding (relation) of in monocyte associated with fibrosis
4) Confidence 0.37 Published 2002 Journal Pancreas Section Abstract Doc Link 12409843 Disease Relevance 0.55 Pain Relevance 0.41
In our study the association between MCP-1 and abnormal glucose regulation was present in the majority of the patients, but not in patients with triglycerides above 1.8 mmol/L, suggesting that in these patients the high levels of triglycerides may mask the association between MCP-1 and glucose regulation.
MCP-1 Binding (association) of
5) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.65 Pain Relevance 0.03
Triglycerides were shown to modify the association between MCP-1 and abnormal glucose regulation (Table A online).
MCP-1 Binding (association) of
6) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.12 Pain Relevance 0.06
CRP and MCP-1 were associated with abnormal glucose regulation independently of each other, indicating that these markers probably are involved in different pathological processes associated with type 2-diabetes.
MCP-1 Binding (associated) of associated with pathologic processes and diabetes mellitus
7) Confidence 0.28 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.86 Pain Relevance 0.06
In our study the association between MCP-1 and abnormal glucose regulation was present in the majority of the patients, but not in patients with triglycerides above 1.8 mmol/L, suggesting that in these patients the high levels of triglycerides may mask the association between MCP-1 and glucose regulation.
MCP-1 Binding (association) of
8) Confidence 0.28 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.83 Pain Relevance 0.06
Furthermore, vMIP-II inhibits the chemotactic activity of the rat chemokines CCL2 (MCP-1), CCL4 (MIP-1?)
MCP-1 Binding (activity) of associated with chemokine
9) Confidence 0.25 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.18 Pain Relevance 0.52
Furthermore, vMIP-II inhibits the chemotactic activity of the rat chemokines CCL2 (MCP-1), CCL4 (MIP-1?)
CCL2 Binding (activity) of associated with chemokine
10) Confidence 0.25 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.18 Pain Relevance 0.52
Other groups reported that gene transfer of plasmid DNA encoding vMIP-II into murine cardiac allografts resulted in a prolonged survival time of allografts and a marked decrease in donor-specific cytotoxic T lymphocytes (CTL) infiltrating the grafts with an inhibition of alloantibody production [8]. vMIP-II administration has been reported to reduce leukocyte infiltration and glomerulitis in an experimental model of glomerulonephritis by reducing the chemotactic activity of MCP-1, MIP-1?
MCP-1 Binding (activity) of in leukocyte associated with renal disease
11) Confidence 0.25 Published 2010 Journal World J Urol Section Body Doc Link PMC2908759 Disease Relevance 0.26 Pain Relevance 0.36
IL-1Ra infusion did not affect MCP-1 immunoreactivity after SE (data not shown).
MCP-1 Binding (immunoreactivity) of associated with status epilepticus
12) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.98 Pain Relevance 0
Surprisingly, monocyte chemoattractant protein-1 (MCP-1), a serum factor gene and chemokine that is in our predictor gene list, was shown to have its protein product differentially expressed in acetaminophen-treated rats [22] and is induced by TNF-?
MCP-1 Binding (have) of in monocyte associated with chemokine and paracetamol
13) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.73 Pain Relevance 0.40
Surprisingly, monocyte chemoattractant protein-1 (MCP-1), a serum factor gene and chemokine that is in our predictor gene list, was shown to have its protein product differentially expressed in acetaminophen-treated rats [22] and is induced by TNF-?
monocyte chemoattractant protein-1 Binding (have) of in monocyte associated with chemokine and paracetamol
14) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.74 Pain Relevance 0.40
Surprisingly, monocyte chemoattractant protein-1 (MCP-1), a serum factor gene and chemokine that is in our predictor gene list, was shown to have its protein product differentially expressed in acetaminophen-treated rats [22] and is induced by TNF-?
MCP-1 Binding (shown) of in monocyte associated with chemokine and paracetamol
15) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.73 Pain Relevance 0.40
Surprisingly, monocyte chemoattractant protein-1 (MCP-1), a serum factor gene and chemokine that is in our predictor gene list, was shown to have its protein product differentially expressed in acetaminophen-treated rats [22] and is induced by TNF-?
monocyte chemoattractant protein-1 Binding (shown) of in monocyte associated with chemokine and paracetamol
16) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2478688 Disease Relevance 0.74 Pain Relevance 0.40
However, we also examined the expression of IP-10 and MCP-1, which recruit T cells and monocytes/macrophages, respectively, because such chemokines are released by mastocytes, macrophages and fibroblasts resident in the inflamed tissue.
MCP-1 Spec (examined) Binding (recruit) of in macrophages associated with chemokine
17) Confidence 0.23 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.60 Pain Relevance 0.56
In the present study, MCP-1 immunoreactivity was detected in microglia, and CCR2 immunoreactivity was colocalized with MIP-2 immunoreactivity in astrocytes and neurons after SE.
MCP-1 Binding (immunoreactivity) of in neurons associated with status epilepticus
18) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.51 Pain Relevance 0.08
In vitro effects of CCL2, which preferentially binds to CCR2 receptor [21,32], were blocked by AZ889 suggesting a specific CCR2 excitatory mechanism.
CCL2 Binding (binds) of
19) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.25 Pain Relevance 0.57
However, we also examined the expression of IP-10 and MCP-1, which recruit T cells and monocytes/macrophages, respectively, because such chemokines are released by mastocytes, macrophages and fibroblasts resident in the inflamed tissue.
MCP-1 Spec (examined) Binding (recruit) of in fibroblasts associated with chemokine
20) Confidence 0.08 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.60 Pain Relevance 0.56

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