INT106262

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Context Info
Confidence 0.24
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 8.81
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver lobes 2
N1-S1 1
portal vein 1
body 1
R3hcc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 4 92.80 High High
aspirin 3 91.72 High High
cINOD 1 90.40 High High
tolerance 24 84.44 Quite High
methotrexate 5 80.44 Quite High
alcohol 10 30.84 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 485 100.00 Very High Very High Very High
Apoptosis 40 100.00 Very High Very High Very High
Cancer 515 99.28 Very High Very High Very High
Thrombosis 20 99.00 Very High Very High Very High
Pancytopenia 5 97.00 Very High Very High Very High
Recurrence 11 96.20 Very High Very High Very High
Body Weight 1 94.80 High High
Aggression 5 91.20 High High
Metastasis 32 90.96 High High
INFLAMMATION 1 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, ultrasound-guided implantation of N1-S1 cells into liver lobes is an effective means of inducing orthotopic HCC in SD rats.


Positive_regulation (inducing) of HCC in liver lobes associated with hepatocellular cancer
1) Confidence 0.24 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.10 Pain Relevance 0
Another approach of concurrent chemoradiotherapy has been performed in stage IVa HCC patients.68 Han, et al.69 reported promising survival results of conformal RT combined with hepatic arterial chemotherapy of 5-FU and cisplatin in 40 patients with locally advanced HCC with portal vein tumour thrombosis (PVTT).69
Positive_regulation (advanced) of HCC in portal vein associated with cancer, hepatocellular cancer and thrombosis
2) Confidence 0.22 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768232 Disease Relevance 0.97 Pain Relevance 0
Radiofrequency ablation therapy and percutaneous ethanol injection therapy are also used as curative treatments for HCC.5 Because HCC is frequently diagnosed at the intermediate or advanced stages, transarterial chemoembolization (TACE), the most popular nonsurgical alternative, is often used as a palliative treatment,6,7 however, effective only in limited occasion.
Positive_regulation (treatments) of HCC associated with hepatocellular cancer and palliative
3) Confidence 0.22 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768232 Disease Relevance 1.37 Pain Relevance 0.09
These facts highlight the potential therapeutic value of epirubicin in targeting TOP2A in the management of HCC.
Positive_regulation (targeting) of HCC associated with hepatocellular cancer
4) Confidence 0.17 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.24 Pain Relevance 0.11
Short-term and low-dose epirubicin chemotherapy induced apoptosis and neovascularization blockade in HCC
Positive_regulation (induced) of HCC associated with hepatocellular cancer and apoptosis
5) Confidence 0.17 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.49 Pain Relevance 0
To generate orthotopic HCC in immune-competent rats, N1-S1 cells were implanted into the liver lobes of the anesthetized SD rats under the guidance of high resolution US on day 1 (Figure 1a).
Positive_regulation (generate) of HCC in liver lobes associated with hepatocellular cancer
6) Confidence 0.16 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 0.85 Pain Relevance 0
Ultrasound-guided implantation of N1-S1 cells effectively induced orthotopic HCC in SD rats
Positive_regulation (induced) of HCC in N1-S1 associated with hepatocellular cancer
7) Confidence 0.16 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 0.85 Pain Relevance 0
Administration for 8 weeks after induction of highly metastatic HCC by sequential treatment with diethylnitrosamine and N-nitrosomorpholine did not cause any significant change in survival rate or body weight.
Positive_regulation (induction) of HCC in body associated with body weight and hepatocellular cancer
8) Confidence 0.08 Published 2002 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 12417048 Disease Relevance 0.94 Pain Relevance 0.17

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