INT106264

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 10.47
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
macrophages 5
endothelium 3
blood 2
plasma 2
Synovial fluid 2
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 72 99.70 Very High Very High Very High
Infliximab 65 99.70 Very High Very High Very High
aspirin 13 99.32 Very High Very High Very High
Etanercept 1 98.76 Very High Very High Very High
chemokine 17 98.32 Very High Very High Very High
Migraine 2 97.92 Very High Very High Very High
Hyperalgesia 3 97.52 Very High Very High Very High
rheumatoid arthritis 14 97.08 Very High Very High Very High
Inflammation 112 97.00 Very High Very High Very High
Osteoarthritis 6 92.24 High High
Disease Link Frequency Relevance Heat
Adhesions 71 100.00 Very High Very High Very High
Cancer 19 100.00 Very High Very High Very High
Hepatocellular Cancer 8 100.00 Very High Very High Very High
Arthritis 23 99.70 Very High Very High Very High
Psoriasis 79 98.64 Very High Very High Very High
Headache 4 97.92 Very High Very High Very High
Necrosis 13 97.64 Very High Very High Very High
Hyperalgesia 3 97.52 Very High Very High Very High
Rheumatoid Arthritis 14 97.08 Very High Very High Very High
INFLAMMATION 124 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor necrosis factor-alpha (TNF-alpha) neutralization with etanercept or infliximab treatment after induction of AIA significantly reduced both macrophage infiltration and VCAM-1 expression.
Negative_regulation (reduced) of Gene_expression (expression) of VCAM-1 in macrophage associated with necrosis, infliximab, cancer, etanercept and arthritis
1) Confidence 0.53 Published 2009 Journal Pain Section Abstract Doc Link 19560272 Disease Relevance 1.53 Pain Relevance 0.92
Determination of soluble VCAM-1 concentration in blood samples
Negative_regulation (Determination) of Gene_expression (concentration) of VCAM-1 in blood
2) Confidence 0.40 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1599714 Disease Relevance 0.20 Pain Relevance 0
However, expression in HCC of mRNAs for intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, both of which are considered to play key roles in attachment of cancer cells to the endothelium, was significantly suppressed by ASP.
Negative_regulation (suppressed) of Gene_expression (expression) of vascular cell adhesion molecule-1 in endothelium associated with cancer, hepatocellular cancer and adhesions
3) Confidence 0.37 Published 2002 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 12417048 Disease Relevance 1.43 Pain Relevance 0.11
This is likely accomplished by reducing the expression of endothelial adhesion molecules, ICAM-1 and VCAM-1, and by downregulating the production of chemokines [23,24].
Negative_regulation (reducing) of Gene_expression (expression) of VCAM-1 associated with chemokine and adhesions
4) Confidence 0.29 Published 2010 Journal Crit Care Section Body Doc Link PMC2945141 Disease Relevance 1.23 Pain Relevance 0.55
Synovial fluid levels of both ICAM-1 and VCAM-1 were significantly reduced at weeks 1 to 3, compared to the baseline values.
Negative_regulation (reduced) of Gene_expression (levels) of VCAM-1 in Synovial fluid
5) Confidence 0.27 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.80 Pain Relevance 0.32
The data also showed that NF-kappaB activation and its associated gene expressions, such as COX-2, iNOS, VCAM-1 and ICAM-1, were all suppressed by the low dose aspirin supplementation through the inhibition of phosphorylation and degradation of IkappaBalpha via the NIK/IKK pathway.
Negative_regulation (suppressed) of Gene_expression (expressions) of VCAM-1 associated with aspirin
6) Confidence 0.26 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.60 Pain Relevance 0.59
On the other hand, NO reduces MCP-1 expression in macrophages and endothelial cells [19,20] and leads to decreased expressions of cell adhesion molecules such as CD11, CD18, VCAM-1 (vascular cell adhesion molecule-1), and ICAM-1 (intercellular adhesion molecule-1) [21,22], counteracting an adhesion of monocytes to the activated endothelial lining.
Negative_regulation (decreased) of Gene_expression (expressions) of VCAM-1 in macrophages associated with adhesions
7) Confidence 0.20 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.71 Pain Relevance 0.03
RESULTS: (1) The clinical symptoms as frequency and persistent time of angina pectoris in the treated group were bettered significantly after treatment and the dosage of nitroglycerin used decreased (all P < 0.01), showing significant difference when compared with those in the control group (P < 0.05). (2) The effective rates on UAP symptoms and ECG in the treated group were 86.7% and 76.7% respectively, which were significantly higher than those in the control group (70.0% and 63.3%, P < 0.05). (3) Laboratory examination showed in the control group, changes only displayed in the decrease of vWF and ET and increase of NO (all P < 0.05), while in the treated group, plasma levels of vWF, ET, sVCAM-1 and sICAM-1 after treatment significantly decreased and were lower than those in the control group (P < 0.01), but NO elevated significantly and was higher than that in the control group (P < 0.01).
Negative_regulation (decreased) of Gene_expression (levels) of sVCAM-1 in plasma
8) Confidence 0.14 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0
Levels of sVCAM-1 and sICAM-1 significantly decreased in the treated group (P < 0.01), while in the control group, no marked change was found in sVCAM-1 and sICAM-1 (P > 0.05).
Negative_regulation (decreased) of Gene_expression (Levels) of sVCAM-1
9) Confidence 0.07 Published 2003 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 14503056 Disease Relevance 0.14 Pain Relevance 0
On the other hand, NO reduces MCP-1 expression in macrophages and endothelial cells [19,20] and leads to decreased expressions of cell adhesion molecules such as CD11, CD18, VCAM-1 (vascular cell adhesion molecule-1), and ICAM-1 (intercellular adhesion molecule-1) [21,22], counteracting an adhesion of monocytes to the activated endothelial lining.
Negative_regulation (decreased) of in endothelial cells Gene_expression (expressions) of VCAM-1 in macrophages associated with adhesions
10) Confidence 0.07 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.71 Pain Relevance 0.03
B and AP-1 transactivation resulting in suppressing the expression of proinflammatory genes such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and adhesive molecules ICAM-1 and VCAM-1 [45–48].
Negative_regulation (suppressing) of Gene_expression (expression) of VCAM-1
11) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.78 Pain Relevance 0.08
OBJECTIVE: The aim of the present research was to verify the levels of the soluble adhesion molecules sL- and sE-selectins, intercellular adhesion molecule (sICAM)-1, and vascular cell adhesion molecule-1 in serial samples of internal jugular venous blood taken from migraine patients without aura (MWoA) during attacks.
Negative_regulation (verify) of Gene_expression (levels) of vascular cell adhesion molecule-1 in internal jugular associated with epilepsy, migraine and adhesions
12) Confidence 0.03 Published 2006 Journal Headache Section Abstract Doc Link 16492228 Disease Relevance 0.72 Pain Relevance 0.25
In the present study we found that infliximab is capable of reducing the expression of the adhesion molecules ICAM-1, VCAM-1 and E-selectin on endothelium in psoriatic dermis and synovial tissue.
Negative_regulation (reducing) of in endothelium Gene_expression (expression) of VCAM-1 in dermis associated with psoriasis, infliximab and adhesions
13) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464872 Disease Relevance 1.27 Pain Relevance 0.64
0.02) and mean VCAM-1 expression was reduced by 44% (P ?
Negative_regulation (reduced) of Gene_expression (expression) of VCAM-1
14) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464872 Disease Relevance 0.26 Pain Relevance 0.03

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