INT10627

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 3.36
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Lnpep) plasma membrane (Lnpep) intracellular (Lnpep)
cytoplasm (Lnpep)
Anatomy Link Frequency
plasma 8
spike 1
tail 1
SON 1
uterine 1
Lnpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tail-flick 3 100.00 Very High Very High Very High
midbrain 1 99.84 Very High Very High Very High
analgesia 17 99.76 Very High Very High Very High
Intracerebroventricular 2 99.58 Very High Very High Very High
Nerve growth factor 2 99.56 Very High Very High Very High
Nucleus accumbens 24 99.40 Very High Very High Very High
epidural 8 99.36 Very High Very High Very High
narcan 18 98.96 Very High Very High Very High
Spinal cord 3 98.16 Very High Very High Very High
Thalamus 1 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Volume Depletion And Dehydration 1 99.56 Very High Very High Very High
Hypertension 13 98.36 Very High Very High Very High
Dysmenorrhea 5 96.52 Very High Very High Very High
Disease 1 94.36 High High
Obesity 2 94.16 High High
Stress 6 94.12 High High
Pain 2 94.08 High High
Shock 2 93.64 High High
Death 1 91.52 High High
Premature Birth 1 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is assumed that the increase in the oxytocinase activity in the course of continuous epidural analgesia is associated with diminished uterine contractions and is related to the effect of the particular anesthetic agent.
Positive_regulation (increase) of oxytocinase in uterine associated with dismenorea, epidural and analgesia
1) Confidence 0.69 Published 1980 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 7446007 Disease Relevance 0.10 Pain Relevance 0.62
The increased oxytocinase activity was found to correlate with the duration of the first stage of labor.
Positive_regulation (increased) of oxytocinase
2) Confidence 0.69 Published 1980 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 7446007 Disease Relevance 0 Pain Relevance 0.61
With the dominating profile of the steady increase of oxytocinase (>90% of cases), the target values are higher than in the case of irregular growth.
Positive_regulation (increase) of oxytocinase
3) Confidence 0.64 Published 2001 Journal Early Pregnancy Section Abstract Doc Link 11753505 Disease Relevance 0.49 Pain Relevance 0.07
OBJECTIVE: Placental Leucine Aminopeptiadse (P-LAP) also known as oxytocinase, is secreted by syncytiotrophoblast and increases gradually during pregnancy until delivery.
Positive_regulation (increases) of P-LAP in syncytiotrophoblast
4) Confidence 0.60 Published 2010 Journal Neuro Endocrinol. Lett. Section Abstract Doc Link 20150869 Disease Relevance 0.25 Pain Relevance 0.14
RESULTS: Significantly increased oxytocinase plasma level was identified during pregnancy, progressive rise was observed beginning with the first trimester of pregnancy, until the labor.
Positive_regulation (increased) of oxytocinase in plasma
5) Confidence 0.52 Published 2005 Journal Neuro Endocrinol. Lett. Section Body Doc Link 16136013 Disease Relevance 0 Pain Relevance 0
The secretory activity of these neurons can be stimulated with physiological manipulations that elevate plasma levels of vasopressin (VP), such as dehydration and salt-loading.
Positive_regulation (elevate) of VP in plasma associated with volume depletion and dehydration
6) Confidence 0.52 Published 1986 Journal Fed. Proc. Section Abstract Doc Link 2874054 Disease Relevance 0.10 Pain Relevance 0.04
When PC12 cells were differentiated into neuronal cells by nerve growth factor (NGF), a significant increase in the expression level of P-LAP in the cell was observed.
Positive_regulation (increase) of P-LAP in nerve associated with nerve growth factor
7) Confidence 0.37 Published 2001 Journal Eur. J. Biochem. Section Abstract Doc Link 11389728 Disease Relevance 0.09 Pain Relevance 0.20
Ir-vasopressin (VP) was not affected in these tissues but increased in midbrain.
Neg (not) Positive_regulation (increased) of VP in midbrain associated with midbrain
8) Confidence 0.32 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860600 Disease Relevance 0.44 Pain Relevance 0.58
In addition, posterior pituitary stimulation increased plasma VP to a level ten times higher than that after footshocks but did not significantly change the threshold.
Neg (not) Positive_regulation (increased) of VP in plasma
9) Confidence 0.28 Published 1988 Journal Jpn. J. Physiol. Section Abstract Doc Link 3221526 Disease Relevance 0 Pain Relevance 0.29
Intravenous VP increased the threshold only in doses that are considered to elevate plasma VP to a level more than 500 times higher than that after footshocks.
Positive_regulation (elevate) of VP in plasma
10) Confidence 0.28 Published 1988 Journal Jpn. J. Physiol. Section Abstract Doc Link 3221526 Disease Relevance 0 Pain Relevance 0.29
The placental leucine aminopeptidase (P-LAP)/oxytocinase whose serum level increases with gestation is thought to contribute to the maintenance of normal pregnancy.
Positive_regulation (increases) of P-LAP
11) Confidence 0.25 Published 2001 Journal Eur. J. Biochem. Section Abstract Doc Link 11389728 Disease Relevance 0.05 Pain Relevance 0.03
These results suggest that the SFO efferents through the MnPO to the PVN may transmit the neuromodulatory signals which evoke long-duration increases in the excitability of putative vasopressin (VP)-secreting neurons in the PVN.
Positive_regulation (increases) of VP in PVN
12) Confidence 0.21 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179725 Disease Relevance 0 Pain Relevance 0.18
Footshocks significantly increased threshold temperature of tail flick and plasma VP as reported previously.
Positive_regulation (increased) of VP in plasma associated with tail-flick
13) Confidence 0.19 Published 1988 Journal Jpn. J. Physiol. Section Abstract Doc Link 3221526 Disease Relevance 0 Pain Relevance 0.29
Plasma levels of vasopressin (VP), which were also elevated in control rats 1 h after NTS lesions, were not significantly altered in SAD rats.
Positive_regulation (elevated) of VP in Plasma
14) Confidence 0.17 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1510167 Disease Relevance 0.10 Pain Relevance 0.09
Supraoptic nucleus (SON) neurons receive a dense innervation from noradrenergic fibers, the activity of which stimulates vasopressin (VP) and oxytocin (OT) release, notably during homeostatic regulation of blood pressure and volume.
Positive_regulation (stimulates) of VP in SON
15) Confidence 0.15 Published 2007 Journal Neuroscience Section Abstract Doc Link 17693027 Disease Relevance 0 Pain Relevance 0.06
Concurrently recorded NAS unit responses to electrical stimulation of the VP were also excited.
Positive_regulation (stimulation) of VP in NAS associated with nucleus accumbens
16) Confidence 0.13 Published 1995 Journal Synapse Section Abstract Doc Link 7570348 Disease Relevance 0 Pain Relevance 1.10
In addition, experiments were conducted to determine whether NAS unit responses to electrical stimulation of the VP were likely to involve cell body as opposed to axonal activations.
Spec (whether) Positive_regulation (stimulation) of VP in cell body associated with nucleus accumbens
17) Confidence 0.13 Published 1995 Journal Synapse Section Abstract Doc Link 7570348 Disease Relevance 0 Pain Relevance 1.10
Bath applications of Arg8-vasopressin (VP) induced a slow-onset membrane depolarization accompanied by spike discharges and membrane oscillations.
Positive_regulation (induced) of VP in spike
18) Confidence 0.10 Published 1998 Journal Prog. Brain Res. Section Abstract Doc Link 10074794 Disease Relevance 0 Pain Relevance 0.21
In extrahypothalamic tissues, [VP] in the hippocampal commissure-fornix was increased in the SHR.
Positive_regulation (increased) of VP in fornix
19) Confidence 0.08 Published 1985 Journal Brain Res. Section Abstract Doc Link 3978414 Disease Relevance 0.37 Pain Relevance 0.46
The pituitary content, plasma concentration, and urinary excretion of OT were reduced (P less than 0.05) in SHRs, whereas VP content was increased (P less than 0.05) in the pituitary and plasma, but unchanged in urine, of hypertensive animals.
Positive_regulation (increased) of VP in plasma associated with hypertension
20) Confidence 0.08 Published 1985 Journal Brain Res. Section Abstract Doc Link 3978414 Disease Relevance 0.37 Pain Relevance 0.36

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