INT106272

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 39
Total Number 45
Disease Relevance 32.08
Pain Relevance 24.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
microglia 19
Spinal 6
neurons 5
plasma 4
RVM 4
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 275 100.00 Very High Very High Very High
cINOD 35 100.00 Very High Very High Very High
Inflammatory response 28 100.00 Very High Very High Very High
Inflammation 432 99.98 Very High Very High Very High
Eae 112 99.98 Very High Very High Very High
Stimulus evoked pain 30 99.98 Very High Very High Very High
Thermal hyperalgesia 75 99.92 Very High Very High Very High
Peripheral nerve injury 34 99.84 Very High Very High Very High
intrathecal 225 99.80 Very High Very High Very High
Brush evoked pain 24 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 447 100.00 Very High Very High Very High
Nervous System Injury 252 100.00 Very High Very High Very High
Myocardial Infarction 79 100.00 Very High Very High Very High
Hypersensitivity 117 99.98 Very High Very High Very High
Injury 105 99.98 Very High Very High Very High
Hyperalgesia 190 99.92 Very High Very High Very High
Neuropathic Pain 220 99.80 Very High Very High Very High
Cv General 4 Under Development 14 99.58 Very High Very High Very High
Nociception 80 99.52 Very High Very High Very High
Inflammatory Pain 44 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia.
Spec (whether) Positive_regulation (necessary) of Spec (whether) Positive_regulation (activation) of p38 in microglia
1) Confidence 0.70 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17667577 Disease Relevance 0.35 Pain Relevance 0.22
CONCLUSIONS: After nerve injury, activity in the peripheral nerve is required for the induction but not the maintenance of p38 activation in spinal microglia.


Positive_regulation (induction) of Positive_regulation (activation) of p38 in nerve
2) Confidence 0.50 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0 Pain Relevance 0
Inflammation induced the activation of p38 MAPK in the RVM, with a peak at 30 min after the injection of CFA into the hindpaw, which lasted for 1 h.
Positive_regulation (induced) of Positive_regulation (activation) of p38 in RVM associated with inflammation and rostral ventromedial medulla
3) Confidence 0.50 Published 2007 Journal Brain Res. Section Abstract Doc Link 17196178 Disease Relevance 0.41 Pain Relevance 0.61
In the present study we examined antinociceptive effects of intrathecal (IT) administration of minocycline in experimental models of inflammation-evoked hyperalgesia in addition to the effect of minocycline on stimulation-induced activation of p38 in spinal microglia.
Positive_regulation (stimulation-induced) of Spec (examined) Positive_regulation (activation) of p38 in microglia associated with hyperalgesia, inflammation, antinociceptive and intrathecal
4) Confidence 0.50 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.65 Pain Relevance 0.77
Spinal NMDA-evoked prostaglandin release and nociception has been linked to the activation of p38 mitogen activated protein kinase (p38).
Positive_regulation (activation) of Positive_regulation (activation) of p38 in Spinal associated with nociception
5) Confidence 0.48 Published 2005 Journal Neuropeptides Section Abstract Doc Link 16176831 Disease Relevance 0.19 Pain Relevance 0.58
Spinal NMDA-evoked prostaglandin release and nociception has been linked to the activation of p38 mitogen activated protein kinase (p38).
Positive_regulation (activation) of Positive_regulation (activation) of p38 in Spinal associated with nociception
6) Confidence 0.48 Published 2005 Journal Neuropeptides Section Abstract Doc Link 16176831 Disease Relevance 0.19 Pain Relevance 0.59
production followed by p38 activation.
Positive_regulation (followed) of Positive_regulation (activation) of p38
7) Confidence 0.48 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.90 Pain Relevance 0.55
In contrast, the CCI induced the activation of p38, mainly in uninjured small-to-medium-diameter DRG neurons and in satellite glial cells.
Positive_regulation (induced) of Positive_regulation (activation) of p38 in DRG associated with dorsal root ganglion and eae
8) Confidence 0.47 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.48 Pain Relevance 1.03
This lesion results in activation of p38 in the L5 segment of the spinal cord, most prominently in the ipsilateral dorsal horn, starting soon after the lesion (<1 d) and persisting for >3 weeks.
Positive_regulation (results) of Positive_regulation (activation) of p38 in dorsal horn associated with dorsal horn and spinal cord
9) Confidence 0.46 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12764087 Disease Relevance 0.59 Pain Relevance 0.73
Activation of p38 in microglia was induced from 1 d and peaked at 3 d, then returned to baseline by 7 d, which was completely consistent with the time course of thermal hyperalgesia.
Positive_regulation (induced) of Positive_regulation (Activation) of p38 in microglia associated with thermal hyperalgesia
10) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2391153 Disease Relevance 1.14 Pain Relevance 0.90
could either be the result of p38 phosphorylation or the cause of p38 activation in neurons and microglia in inflammation.
Positive_regulation (cause) of Positive_regulation (activation) of p38 in microglia associated with inflammation
11) Confidence 0.44 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.95 Pain Relevance 1.11
Taken together our results demonstrate that activation of P2X4 or p38 MAPK in spinal cord microglia is necessary for tactile allodynia following nerve injury.
Positive_regulation (necessary) of Positive_regulation (activation) of p38 in nerve associated with brush evoked pain, nervous system injury and spinal cord
12) Confidence 0.44 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.07 Pain Relevance 0.91
The intrathecal infusion of the P2Y(12) agonist 2-(methythio) adenosine 5'-diphosphate trisodium salt into naive rats mimicked the nerve injury-induced activation of p38 in microglia and elevated pain behaviors.
Positive_regulation (injury-induced) of Positive_regulation (activation) of p38 in microglia associated with pain, adenocard, nervous system injury, agonist and intrathecal
13) Confidence 0.42 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18337420 Disease Relevance 0.95 Pain Relevance 0.96
ATP causes the activation of p38 or ERK1/2, mitogen activated protein kinases (MAPKs) resulting in the release of tumor necrosis factor-alpha (TNF) and Interleukin-6 (IL-6) from microglia.
Positive_regulation (causes) of Positive_regulation (activation) of p38 in microglia associated with necrosis and cancer
14) Confidence 0.38 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.42 Pain Relevance 0.07
Here we examined the anti-nociceptive effects of intrathecal (IT) administration of 1400W in two experimental models of hyperalgesia (formalin and carrageenan models), in addition to the effect of 1400W on stimulation-induced activation of spinal p38 mitogen-activated protein kinase (p38).
Positive_regulation (stimulation-induced) of Positive_regulation (activation) of p38 in spinal associated with nociception, hyperalgesia and intrathecal
15) Confidence 0.36 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17561811 Disease Relevance 0.65 Pain Relevance 0.55
Mitogen activated protein kinase (MAPK) p38 is activated after ischemic events and angiotensin II [21-23].
Positive_regulation (activated) of Positive_regulation (activated) of p38
16) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.42 Pain Relevance 0.07
These results demonstrate that neuropathic pain hypersensitivity depends upon the activation of p38 signaling pathway in microglia in the dorsal horn following peripheral nerve injury.
Positive_regulation (depends) of Positive_regulation (activation) of p38 in peripheral nerve associated with nervous system injury, hypersensitivity, neuropathic pain, dorsal horn, stimulus evoked pain and peripheral nerve injury
17) Confidence 0.35 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 1.05 Pain Relevance 0.73
METHODS: Rat PSCs were incubated with ethanol (50 mM) or acetaldehyde (200 microM) for 15 min, 30 min, 60 min, and 24 h; and activities of ERK 1/2, JNK, and p38 kinase were assessed in cell lysates using kinase assays and Western blot.
Positive_regulation (assessed) of Positive_regulation (activities) of p38 in PSCs
18) Confidence 0.35 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
RESULTS: Ethanol and acetaldehyde increased the activation of all 3 subfamilies (ERK 1/2, JNK and p38 kinase) of the MAPK pathway in PSCs.
Positive_regulation (increased) of Positive_regulation (activation) of p38 in PSCs
19) Confidence 0.35 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
Taken together, our results demonstrate that the activation of ERK and p38 and also the changes in NPY and BDNF expression may occur in different populations of DRG neurons after CCI, partially through alterations in the target-derived NGF.
Spec (may) Positive_regulation (occur) of Positive_regulation (activation) of p38 in neurons associated with dorsal root ganglion, nerve growth factor and eae
20) Confidence 0.34 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.37 Pain Relevance 1.17

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