INT106273

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Context Info
Confidence 0.29
First Reported 2002
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.22
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
nucleus 2
brainstem 2
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 4 98.80 Very High Very High Very High
Central nervous system 3 93.60 High High
Migraine 11 86.84 High High
Multiple sclerosis 2 86.32 High High
headache 2 82.64 Quite High
Inflammation 2 71.96 Quite High
Disease Link Frequency Relevance Heat
Headache 13 86.84 High High
Demyelinating Disease 2 86.32 High High
Disease 2 79.64 Quite High
INFLAMMATION 2 71.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis confirmed the activation of the NF-kappaB pathway showing an increase in the optical density of p65 in nuclear extracts of lower brainstem of rats injected with the nitric oxide (NO) donor.
Positive_regulation (activation) of Positive_regulation (increase) of p65 in brainstem associated with medulla
1) Confidence 0.29 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936821 Disease Relevance 0.45 Pain Relevance 0.58
A significant increase of nuclear immunostaining of p65, an indicator of NF-kappaB activation, was detected in lamina I and II of nucleus trigeminalis caudalis in rats injected with NTG when compared with the control group.
Positive_regulation (increase) of Positive_regulation (activation) of p65 in nucleus
2) Confidence 0.26 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936821 Disease Relevance 0.44 Pain Relevance 0.54
Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation.
Positive_regulation (activation) of Neg (not) Positive_regulation (activation) of p65
3) Confidence 0.21 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12417429 Disease Relevance 0.33 Pain Relevance 0.30

General Comments

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