INT106274

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 9.76
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
neurons 3
nucleus 3
neuronal 1
vessels 1
spleen 1
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 19 99.12 Very High Very High Very High
medulla 25 98.80 Very High Very High Very High
Inflammation 140 97.92 Very High Very High Very High
Spinal nerve ligature 39 97.36 Very High Very High Very High
dorsal root ganglion 3 97.20 Very High Very High Very High
Sciatic nerve 3 97.12 Very High Very High Very High
allodynia 27 94.20 High High
Central nervous system 9 93.60 High High
Action potential 17 93.12 High High
Neuropathic pain 54 92.40 High High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 9 99.90 Very High Very High Very High
Stress 11 99.68 Very High Very High Very High
Periodontitis 60 99.56 Very High Very High Very High
Headache 21 99.12 Very High Very High Very High
INFLAMMATION 162 97.92 Very High Very High Very High
Pancreatitis 156 97.72 Very High Very High Very High
Obstructive Jaundice 144 97.40 Very High Very High Very High
Ganglion Cysts 36 96.24 Very High Very High Very High
Neuropathic Pain 87 94.20 High High
Alveolar Bone Loss 14 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B p65 is not activated or only shows weak activity in the spleen and thymus of SAP and OJ rats.
Neg (not) Positive_regulation (activated) of p65 in thymus associated with pancreatitis and obstructive jaundice
1) Confidence 0.67 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.52 Pain Relevance 0.11
A significant increase in nuclear content of p65, an indicator of NF-kappaB activation, was detected in trigeminal nucleus caudalis in rats following injection with nitroglycerin.
Positive_regulation (increase) of p65 in nucleus
2) Confidence 0.47 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.34 Pain Relevance 0.32
B p65 is activated and binds to specific ?
Positive_regulation (activated) of p65
3) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.36 Pain Relevance 0.14
A significant increase of nuclear immunostaining of p65, an indicator of NF-kappaB activation, was detected in lamina I and II of nucleus trigeminalis caudalis in rats injected with NTG when compared with the control group.
Positive_regulation (activation) of p65 in nucleus
4) Confidence 0.39 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936821 Disease Relevance 0.44 Pain Relevance 0.53
For the anti-synaptotagmin-1-cypHer experiments cultured dispersed hippocampal neurons were incubated for 0.5 h to 1 h with 0.6 µg of CypHer™5E labelled anti-synaptotagmin1 antibody (?
Positive_regulation (incubated) of synaptotagmin1 in neurons
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958124 Disease Relevance 0 Pain Relevance 0.38
A significant increase in nuclear content of p65, an indicator of NF-kappaB activation, was detected in trigeminal nucleus caudalis in rats following injection with nitroglycerin.
Positive_regulation (activation) of p65 in nucleus
6) Confidence 0.31 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.34 Pain Relevance 0.32
Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation.
Neg (not) Positive_regulation (activation) of p65
7) Confidence 0.29 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12417429 Disease Relevance 0.31 Pain Relevance 0.28
Western blot analysis confirmed the activation of the NF-kappaB pathway showing an increase in the optical density of p65 in nuclear extracts of lower brainstem of rats injected with the nitric oxide (NO) donor.
Positive_regulation (increase) of p65 in brainstem associated with medulla
8) Confidence 0.29 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936821 Disease Relevance 0.45 Pain Relevance 0.58
B p65 is not activated or only shows weak activity in the spleen and thymus of SAP and OJ rats.
Neg (not) Positive_regulation (activated) of p65 in spleen associated with pancreatitis and obstructive jaundice
9) Confidence 0.23 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.52 Pain Relevance 0.11
Interestingly, using our neuronal induction protocol, we also observed that genes implicated in neurogenesis are increased and specially those in relation with the synaptic transmission (AMPA, synaptotagmin, CASK, Syntaxin 1A, SNCAIP, MCT2).
Positive_regulation (increased) of synaptotagmin in neuronal associated with neurodegenerative disease
10) Confidence 0.20 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.10 Pain Relevance 0
B subunit p65 was increased in the endothelium, smooth muscles cells of damaged small vessels, and infiltrated cells in dTGR.
Positive_regulation (increased) of p65 in vessels
11) Confidence 0.13 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.71 Pain Relevance 0.11
In addition, periodontitis caused a significant increase in the NF-kB p65 levels in the nuclear fractions from of gingivomucosal tissues from operated rats (Figure 3b, b1) compared to the of gingivomucosal tissues from the contralateral side (Figure 3b, b1).
Positive_regulation (increase) of p65 associated with periodontitis
12) Confidence 0.11 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.43 Pain Relevance 0
B p65 activation
Positive_regulation (activation) of p65
13) Confidence 0.11 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.53 Pain Relevance 0
B p65 was increased in all injured animals and decreased by progesterone treatment in comparison to vehicle-treated animals.
Positive_regulation (increased) of p65
14) Confidence 0.10 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.32 Pain Relevance 0
Changes in gene expression, including a decrease in ZAS3 and an increase in the p65 subunit of NF-?
Positive_regulation (increase) of p65
15) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1361774 Disease Relevance 0.73 Pain Relevance 0.80
A similar increase and activation (that is nuclear localization) of p65-IR was observed in ipsilateral DRG neurons after tight ligation of the sciatic nerve [40].
Positive_regulation (increase) of p65 in neurons associated with sciatic nerve
16) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.33 Pain Relevance 0.21
A similar increase and activation (that is nuclear localization) of p65-IR was observed in ipsilateral DRG neurons after tight ligation of the sciatic nerve [40].
Positive_regulation (activation) of p65 in neurons associated with sciatic nerve
17) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.33 Pain Relevance 0.21

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