INT106283

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.61
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cnr1) plasma membrane (Cnr1) response to stress (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
nerve 2
Cnr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 18 100.00 Very High Very High Very High
antagonist 13 99.38 Very High Very High Very High
qutenza 53 99.12 Very High Very High Very High
agonist 41 99.06 Very High Very High Very High
Cannabinoid 52 98.88 Very High Very High Very High
Hyperalgesia 8 98.80 Very High Very High Very High
analgesia 7 98.12 Very High Very High Very High
Deafferentation 2 97.82 Very High Very High Very High
Periaqueductal grey 10 97.24 Very High Very High Very High
Endocannabinoid 16 93.32 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 9 100.00 Very High Very High Very High
Hyperalgesia 8 98.80 Very High Very High Very High
Urological Neuroanatomy 11 97.24 Very High Very High Very High
Hyperphagia 2 90.00 High High
Cystitis 1 85.12 High High
Overactive Bladder 25 78.32 Quite High
Nociception 22 77.64 Quite High
Pain 42 52.44 Quite High
Fever 4 37.64 Quite Low
Neuropathic Pain 8 30.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin deafferentation abolished the peripheral effects of both cannabinoid agonists and antagonists, suggesting that these agents modulate food intake by acting on CB1 receptors located on capsaicin-sensitive sensory terminals.
Regulation (modulate) of Positive_regulation (acting) of CB1 associated with qutenza, antagonist, cannabinoid, agonist and deafferentation
1) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12417686 Disease Relevance 0.18 Pain Relevance 0.74
The pre-synaptic inhibitory effect of anandamide is evident at low concentration and at higher concentrations the activation of TRPV1 counters the effect on CB1/CB2 receptors.[19] The activation of TRPV1 channels can lead to desensitization and loss of pre-synaptic inhibition observed in various studies.[28]
Regulation (effect) of Positive_regulation (activation) of CB1
2) Confidence 0.35 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 0.59 Pain Relevance 0.28
Here, we examined the hypothesis that the upregulation of spinal CB1R induced by chronic constriction nerve injury (CCI) in rats would be regulated by spinal GR.
Regulation (regulated) of Spec (examined) Positive_regulation (induced) of CB1R in nerve associated with nervous system injury
3) Confidence 0.15 Published 2007 Journal Pain Section Abstract Doc Link 17258396 Disease Relevance 0.70 Pain Relevance 0.46
This effect was shown to be dependent on the activation of TRPV1 and CB1 (cannabinoid receptor-1) receptors.
Regulation (dependent) of Positive_regulation (activation) of cannabinoid receptor-1 associated with cannabinoid receptor
4) Confidence 0.11 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 1.14 Pain Relevance 1.57

General Comments

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