INT106286

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.24
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (UCP2) mitochondrion (UCP2) small molecule metabolic process (UCP2)
Anatomy Link Frequency
spinal cord 2
telomere 2
neurons 1
brain 1
substantia gelatinosa 1
UCP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 20 99.92 Very High Very High Very High
substance P 5 99.76 Very High Very High Very High
substantia gelatinosa 5 99.68 Very High Very High Very High
ischemia 24 98.94 Very High Very High Very High
Glutamate receptor 9 95.48 Very High Very High Very High
Pain 17 95.04 Very High Very High Very High
Inflammatory response 18 94.40 High High
Central nervous system 22 76.16 Quite High
Dopamine 10 76.00 Quite High
aspirin 6 73.56 Quite High
Disease Link Frequency Relevance Heat
Stress 494 99.86 Very High Very High Very High
Diabetes Mellitus 533 99.52 Very High Very High Very High
Brain Injury 2 99.48 Very High Very High Very High
Lifespan 83 99.12 Very High Very High Very High
Cv Unclassified Under Development 22 98.94 Very High Very High Very High
Obesity 51 98.24 Very High Very High Very High
Apoptosis 18 96.64 Very High Very High Very High
Pain 12 95.04 Very High Very High Very High
INFLAMMATION 61 94.40 High High
Injury 8 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also report for the first time an association of shorter leukocyte telomeres in T2D patients with variation affecting the UCP2 gene expression.
Gene_expression (expression) of UCP2 in telomeres associated with diabetes mellitus
1) Confidence 0.77 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.59 Pain Relevance 0
To maintain homeostasis, UCP2 expression is induced by elevated oxygen species concentration [21].
Gene_expression (expression) of UCP2
2) Confidence 0.77 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.85 Pain Relevance 0
Decreased UCP2 expression results in increased ROS production, in vitro [19], while animal studies have shown that absence of UCP2 causes higher oxidative stress [20].
Gene_expression (expression) of UCP2 associated with stress
3) Confidence 0.77 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.87 Pain Relevance 0
In all of these areas, UCP2 expression was associated with axons and axon terminals and direct appositions between UCP2-immunoreactive fibers and NMDA glutamate receptors-containing perikarya were frequently detected.
Gene_expression (expression) of UCP2 associated with glutamate receptor
4) Confidence 0.75 Published 2002 Journal Brain Res. Section Abstract Doc Link 12419545 Disease Relevance 0.07 Pain Relevance 0.45
In this study, we explored the expression of UCP2 in the spinal cord.
Gene_expression (expression) of UCP2 in spinal cord associated with spinal cord
5) Confidence 0.75 Published 2002 Journal Brain Res. Section Abstract Doc Link 12419545 Disease Relevance 0.07 Pain Relevance 0.41
The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation.
Gene_expression (expression) of UCP2 in spinal cord associated with pain and spinal cord
6) Confidence 0.75 Published 2002 Journal Brain Res. Section Abstract Doc Link 12419545 Disease Relevance 0.17 Pain Relevance 0.48
UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord.
Gene_expression (expressed) of UCP2 in ventral associated with substantia gelatinosa and spinal cord
7) Confidence 0.75 Published 2002 Journal Brain Res. Section Abstract Doc Link 12419545 Disease Relevance 0.07 Pain Relevance 0.43
As such, after ischemia and traumatic brain injury, both involving OS, high expression of Ucp2 is neuroprotective through activation of neuronal redox signaling or prevention of apoptosis (Mattiasson et al., 2003b).
Gene_expression (expression) of Ucp2 in brain associated with stress, ischemia, apoptosis and brain injury
8) Confidence 0.70 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.97 Pain Relevance 0.26
Consistent with the higher ROS production and selective vulnerability of hippocampal CA1, neurons in this region exhibit lower expression of Ucp2 compared with those in CA3 (Richard et al., 2001).


Gene_expression (expression) of Ucp2 in neurons
9) Confidence 0.70 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.86 Pain Relevance 0.29
Association with UCP2 functional variants
Gene_expression (variants) of UCP2
10) Confidence 0.67 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.50 Pain Relevance 0.04
A common functional variant exists in the promoter of human UCP2 gene (?
Gene_expression (gene) of UCP2
11) Confidence 0.67 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.94 Pain Relevance 0
Differences in telomere length between ethnic groups, tertiles of TAOS, categorical characteristics and UCP2 SNP genotypes were tested using analysis of covariance.
Gene_expression (genotypes) of UCP2 in telomere
12) Confidence 0.67 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.13 Pain Relevance 0
UCP2 was expressed in the substantia gelatinosa and ventral horn of the rodent and primate spinal cord.
Gene_expression (expressed) of UCP2 in substantia gelatinosa associated with substantia gelatinosa and spinal cord
13) Confidence 0.25 Published 2002 Journal Brain Res. Section Abstract Doc Link 12419545 Disease Relevance 0.07 Pain Relevance 0.43
target genes (UCP-2, LPL, p85aPI3K, and PPAR?
Gene_expression (p85aPI3K) of UCP-2
14) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.32 Pain Relevance 0
However, it has been previously shown that
                       the expression of human UCP-2 increases Drosophila lifespan. 
Gene_expression (expression) of UCP-2 associated with lifespan
15) Confidence 0.03 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2880708 Disease Relevance 0.73 Pain Relevance 0

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