INT106307

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 32
Disease Relevance 16.63
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UROD) small molecule metabolic process (UROD) lyase activity (UROD)
nucleolus (UROD) nucleus (UROD) cytoplasm (UROD)
Anatomy Link Frequency
liver 3
T-cell 2
covering 1
plasma 1
neutrophils 1
UROD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 36 99.72 Very High Very High Very High
anesthesia 61 99.00 Very High Very High Very High
Inflammatory response 34 97.52 Very High Very High Very High
cytokine 73 97.40 Very High Very High Very High
Inflammation 103 92.72 High High
cva 5 91.04 High High
corticosteroid 20 89.04 High High
ischemia 40 83.40 Quite High
epidural 1 50.00 Quite Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 428 100.00 Very High Very High Very High
Bacterial Infection 187 99.96 Very High Very High Very High
Sepsis 470 99.56 Very High Very High Very High
INFLAMMATION 160 99.56 Very High Very High Very High
Disease 29 98.84 Very High Very High Very High
Injury 20 98.84 Very High Very High Very High
Organ Transplantation 20 98.56 Very High Very High Very High
Staphylococcus Infection 6 97.80 Very High Very High Very High
Shock 20 94.68 High High
Meningitis 6 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mild PCT elevation can be a marker of surgical trauma.
Positive_regulation (elevation) of PCT associated with injury
1) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.65 Pain Relevance 0.11
In our study, in both groups of patients receiving immunosuppressive therapy, an elevated level of PCT was found, especially in the group of ATG-treated patients.
Positive_regulation (elevated) of PCT
2) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.44 Pain Relevance 0.07
Highly elevated PCT levels were described in patients having undergone immunosuppressive therapy.
Positive_regulation (elevated) of PCT
3) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.64 Pain Relevance 0.10
Transient elevation of PCT due to the immunosuppressive therapy in kidney or liver transplant patients has been described in other studies [5,6,8,9].
Positive_regulation (elevation) of PCT in liver
4) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.41 Pain Relevance 0.08
Thus, it is noticeable that very high levels of PCT (in the range of hundreds of nanograms), even if elevated only transiently, are not connected with the presence of systemic bacterial infection.
Positive_regulation (levels) of PCT associated with bacterial infection
5) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.33 Pain Relevance 0.06
An increased PCT level over the course of the first 24 hours is an independent predictor of all-cause mortality in a 90-day follow-up period [3].
Positive_regulation (increased) of PCT
6) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.55 Pain Relevance 0.13
PCT and CRP levels were measured before the induction of anesthesia, immediately after the surgery, and then daily up to the fourth day after surgery.
Positive_regulation (measured) of PCT associated with anesthesia
7) Confidence 0.40 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.18 Pain Relevance 0.19
The serum levels of PCT and CRP were measured before the induction of anesthesia, in the fourth and eighth hours after graft reperfusion, and continued daily to the fourth day after surgery.
Positive_regulation (levels) of PCT associated with anesthesia
8) Confidence 0.40 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.12 Pain Relevance 0.17
At the beginning of the '90s, it was discovered that elevated levels of serum procalcitonin (PCT) were closely related to the infectious etiology of systemic inflammatory response.
Positive_regulation (elevated) of PCT associated with inflammatory response
9) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.34 Pain Relevance 0.13
The study of Fazakas and colleagues [15] documented only a mild elevation of PCT levels immediately after graft reperfusion in patients after liver transplantation without OKT3 (monoclonal antibody that specifically reacts with the T cell receptor-CD3 complex on the surface of circulating human T cells) or ATG therapy.
Positive_regulation (elevation) of PCT in T cell
10) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.29 Pain Relevance 0.03
At the beginning of the '90s, it was discovered that elevated levels of serum procalcitonin (PCT) were closely related to the infectious etiology of systemic inflammatory response.
Positive_regulation (levels) of PCT associated with inflammatory response
11) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.34 Pain Relevance 0.13
PCT and CRP levels were investigated in two groups of patients undergoing OLTx with different regimens of the immunosuppressive therapy and in one group of patients undergoing liver resection as a surgical control.
Spec (investigated) Positive_regulation (investigated) of PCT in liver
12) Confidence 0.35 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.27 Pain Relevance 0
In the present study the PCT levels increased with increasing severity of infection, with the highest levels in severe sepsis (median 4.4 ng/ml) and in septic shock (median 46.1 ng/ml).
Positive_regulation (increased) of PCT associated with sepsis and infection
13) Confidence 0.34 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 1.29 Pain Relevance 0
Thus, it is noticeable that very high levels of PCT (in the range of hundreds of nanograms), even if elevated only transiently, are not connected with the presence of systemic bacterial infection.
Positive_regulation (elevated) of PCT associated with bacterial infection
14) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.34 Pain Relevance 0.07
Kuse and colleagues [6,8] speculated that systemic cytokine release induced by OKT3/ATG administration could lead to increased enteral permeability with endotoxin translocation causing the PCT increase.
Positive_regulation (increase) of PCT associated with cytokine
15) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.54 Pain Relevance 0.05
Elevated PCT levels have been detected in patients following organ transplantation in a number of studies [4-6].
Positive_regulation (Elevated) of PCT associated with organ transplantation
16) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.64 Pain Relevance 0.11
Elevated levels of PCT were also detected in patients undergoing liver transplant and immunosuppression without ATG therapy; however, peak levels reached only 13.9 ng/mL, again occurring on the first postoperative day (Table 1).
Positive_regulation (levels) of PCT in liver
17) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0 Pain Relevance 0
In patients with ATG administration, PCT levels were highly increased on postoperative day 1 (median 53.0 ng/mL, minimum 7.9 ng/mL, maximum 249.1 ng/mL).
Positive_regulation (increased) of PCT
18) Confidence 0.33 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246230 Disease Relevance 0.08 Pain Relevance 0.08
ATG administration to patients with OLTx is associated with an increase in serum PCT levels, with peak values on postoperative day 1, and this was in the absence of any evidence of infection.
Positive_regulation (increase) of PCT associated with infection
19) Confidence 0.33 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246230 Disease Relevance 0.18 Pain Relevance 0
The regulatory processes connected with such high levels of PCT are complicated to address, and, at present, only hypotheses are available.
Positive_regulation (levels) of PCT
20) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox