INT106330

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 5.57
Pain Relevance 7.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
brain structures 4
lateral column 2
nucleus 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 261 100.00 Very High Very High Very High
agonist 108 100.00 Very High Very High Very High
Lasting pain 28 99.80 Very High Very High Very High
Central nervous system 16 99.68 Very High Very High Very High
bDMF 24 99.12 Very High Very High Very High
addiction 4 98.98 Very High Very High Very High
cocaine 7 98.88 Very High Very High Very High
fluoxetine 34 98.12 Very High Very High Very High
Glutamate 2 97.36 Very High Very High Very High
Spinal cord 22 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 290 100.00 Very High Very High Very High
Pain 57 99.80 Very High Very High Very High
Nociception 28 99.38 Very High Very High Very High
Stress 309 96.52 Very High Very High Very High
Neuropathic Pain 11 95.76 Very High Very High Very High
Cognitive Disorder 18 93.72 High High
Cv General 4 Under Development 64 92.56 High High
Injury 35 84.96 Quite High
Amputation 19 80.32 Quite High
INFLAMMATION 11 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That the two classes of compounds have a synergetic action when chronically administered for three days was confirmed by assessing their combined influence on CREB activation.
Regulation (influence) of Positive_regulation (activation) of CREB
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.22
Using Western blotting and immunocytochemical techniques, we identified key signal transduction pathways operative in phosphorylating CREB in cortical cell cultures and examined their participation in 3 ppm A1254-induced CREB activation.
Spec (examined) Regulation (participation) of Spec (examined) Positive_regulation (activation) of CREB
2) Confidence 0.45 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.21
change in transmission due to CREB induction in the right hemisphere.
Regulation (change) of Positive_regulation (induction) of CREB
3) Confidence 0.45 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.36 Pain Relevance 0.82
Furthermore, they suggest a dependence-associated shift in the molecular mechanisms that regulate the consequences of D1 receptor stimulation, favoring activation of GluR1 rather than CREB.
Regulation (regulate) of Positive_regulation (activation) of CREB associated with addiction
4) Confidence 0.44 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16775132 Disease Relevance 0.07 Pain Relevance 1.46
Here we investigated the alterations on phospho-Ser133 CREB, phospho-Thr34 DARPP-32 and phospho-Thr75 DARPP-32 induced by continuous infusions of cocaine, GBR12909, fluoxetine and nisoxetine.
Spec (investigated) Regulation (alterations) of Positive_regulation (induced) of CREB associated with fluoxetine and cocaine
5) Confidence 0.44 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.60
Again, this hypothesis remains to be experimentally confirmed, and lesion/depletion studies are currently underway in our laboratory to determine the extent to which hippocampal 5-HT4 receptors are involved in the facilitatory effect of 5-HT4 agonists on CREB activation.
Regulation (effect) of Positive_regulation (activation) of CREB associated with agonist
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.41
Moreover, in Handled CREB rats, the increase of pCREB in the right but not left lateral column of the PAG is consistent
Regulation (consistent) of Positive_regulation (increase) of pCREB in lateral column associated with central grey
7) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.32 Pain Relevance 0.61
that in the present study, there was no pCREB increase over control in the left
Neg (no) Regulation (was) of Neg (no) Positive_regulation (increase) of pCREB
8) Confidence 0.39 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.30 Pain Relevance 0.14
These findings suggest that persistent nociception induces differential regional regulation of NK-1 receptor and BDNF gene expression and CREB activation in the CNS, potentially reflecting varied roles of these neuromodulators in the spinal cord during persistent sensory activation vs. modulation of the higher brain structures such as the hippocampus.



Regulation (regulation) of Positive_regulation (activation) of CREB in brain structures associated with nociception, hippocampus, central nervous system and spinal cord
9) Confidence 0.23 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2174921 Disease Relevance 0.45 Pain Relevance 0.56
Furthermore, little is known as to what signaling cascades are responsible for CREB activation, although cAMP-protein kinase A (PKA) cascade was suggested to be a central player.
Regulation (responsible) of Positive_regulation (activation) of CREB
10) Confidence 0.20 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138445 Disease Relevance 0.22 Pain Relevance 0.50
How these signals confer protection is not completely understood, but working hypotheses include up-regulation of endogenous antioxidant mechanisms in the brain (Toyoda et al. 1997), such as superoxide dismutase (Bordet et al. 2000; Kato et al. 1995; Wada et al. 2001), and activation of transcription factors implicated in neuroprotection, such as cyclic AMP-response element binding protein (CREB) (Hara et al. 2003; Tauskela and Morley 2004) and nuclear factor-kappa B (NF-?
Regulation (regulation) of Positive_regulation (activation) of CREB in brain
11) Confidence 0.20 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.14 Pain Relevance 0.08
The expression of p-Erk in the cytoplasm near the nucleus during the induction of chronic pain may play roles in the activation of a series of plasticity-related immediate early genes such as cAMP response element binding protein (CREB) [16].
Regulation (roles) of Positive_regulation (activation) of CREB in nucleus associated with lasting pain
12) Confidence 0.19 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 1.28 Pain Relevance 1.15
Our study adds to these findings by demonstrating a role for extranuclear estrogen receptors in CREB activation via the use of the nuclear impermeable E2 conjugates, demonstrating the importance of ERK and Akt signaling for CREB activation and for elevation of BDNF, and demonstrating a functional role of extranuclear estrogen receptors and the ERK-Akt-CREB-BDNF signaling pathway in preserving cognitive function following GCI.
Regulation (importance) of Positive_regulation (activation) of CREB associated with cognitive disorder, ischemia and bdmf
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.41 Pain Relevance 0.30

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