INT106333

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Olr1254 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 97.74 Very High Very High Very High
Glutamate 4 97.36 Very High Very High Very High
Kinase C 2 78.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tetrodotoxin (1 microM) completely inhibited CREB phosphorylation by A1254, suggesting that synaptic activity is involved in A1254-induced CREB activation.
A1254 Positive_regulation (activation) of CREB associated with tetrodotoxin
1) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.22
Using Western blotting and immunocytochemical techniques, we identified key signal transduction pathways operative in phosphorylating CREB in cortical cell cultures and examined their participation in 3 ppm A1254-induced CREB activation.
A1254 Spec (examined) Positive_regulation (activation) of CREB
2) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.21

General Comments

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