INT106335

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
neurons 2
Olr1254 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 98.72 Very High Very High Very High
tetrodotoxin 5 87.48 High High
Glutamate 10 82.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Buffering [Ca(2+)](i) with bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester in the absence of extracellular Ca(2+) partially inhibited A1254-induced CREB phosphorylation.
A1254 Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB
1) Confidence 0.03 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.21
Inhibition of mitogen-activated protein kinase (10 microM U0126) or protein kinase C (PKC; bisindoylmaleimide, 5 microM) activation did not inhibit A1254-induced CREB phosphorylation.
A1254 Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB associated with kinase c
2) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.20
By contrast, inhibition of protein kinase A (PKA) with 100 microM PKA inhibitor peptide, PKI, blocked A1254-induced CREB phosphorylation.
A1254 Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB
3) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.18
Furthermore, A1254-induced CREB phosphorylation occurs predominantly in neurons, is dependent on synaptic activity and mediated by Ca(2+)- and PKA-dependent pathways.
A1254 Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB in neurons
4) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.13
Aroclor 1254 (A1254), a polychlorinated biphenyl mixture, perturbs Ca(2+) homeostasis and increases CREB phosphorylation in rat neonatal cortical cell cultures in a time- and concentration-dependent manner.
A1254 Positive_regulation (increases) of Phosphorylation (phosphorylation) of CREB
5) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421622 Disease Relevance 0 Pain Relevance 0.04

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