INT106338

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat) plasma membrane (Tacr1) response to stress (Tacr1)
cytoplasm (Tacr1) signal transducer activity (Tacr1)
Anatomy Link Frequency
cortex 7
hippocampus 5
Tacr1 (Rattus norvegicus)
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 20 100.00 Very High Very High Very High
Action potential 6 98.20 Very High Very High Very High
Hippocampus 4 97.40 Very High Very High Very High
tetrodotoxin 10 91.20 High High
Glutamate 15 86.72 High High
Kinase C inhibitor 1 80.72 Quite High
agonist 11 79.92 Quite High
GABAergic 1 78.56 Quite High
substance P 13 76.24 Quite High
Kinase C 2 75.24 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, spontaneous inhibitory postsynaptic currents were increased in frequency and amplitude showing that GABA release was promoted by NK1 receptor activation.
Positive_regulation (activation) of NK1 receptor Positive_regulation (promoted) of Localization (release) of GABA associated with gaba
1) Confidence 0.34 Published 2004 Journal Neuroscience Section Abstract Doc Link 15262336 Disease Relevance 0 Pain Relevance 0.61
The results demonstrate that neurokinin-1 receptor activation promotes the release of GABA at synapses on principal neurones in both entorhinal cortex and hippocampus.
Positive_regulation (activation) of neurokinin-1 receptor in hippocampus Positive_regulation (promotes) of Localization (release) of GABA in hippocampus associated with gaba and hippocampus
2) Confidence 0.32 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421623 Disease Relevance 0 Pain Relevance 0.79
The results demonstrate that neurokinin-1 receptor activation promotes the release of GABA at synapses on principal neurones in both entorhinal cortex and hippocampus.
Positive_regulation (activation) of neurokinin-1 receptor in hippocampus Positive_regulation (promotes) of in cortex Localization (release) of GABA in hippocampus associated with gaba and hippocampus
3) Confidence 0.11 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421623 Disease Relevance 0 Pain Relevance 0.79
Using whole-cell patch-clamp recordings of spontaneous synaptic activity, we have previously shown that activation of neurokinin-1 (NK1) but not NK3 receptors leads to increased GABA release onto principal cells in the rat entorhinal cortex.
Positive_regulation (activation) of neurokinin-1 in cortex Positive_regulation (increased) of Localization (release) of GABA in cortex associated with gaba
4) Confidence 0.09 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12453053 Disease Relevance 0 Pain Relevance 0.41
Using whole-cell patch-clamp recordings of spontaneous synaptic activity, we have previously shown that activation of neurokinin-1 (NK1) but not NK3 receptors leads to increased GABA release onto principal cells in the rat entorhinal cortex.
Positive_regulation (activation) of neurokinin-1 in cortex Positive_regulation (leads) of Localization (release) of GABA in cortex associated with gaba
5) Confidence 0.09 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12453053 Disease Relevance 0 Pain Relevance 0.41

General Comments

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