INT106340

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 7.03
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) plasma membrane (Irs1) nucleus (Irs1)
cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
adipose tissue 4
blood 2
skeletal muscle 2
liver 1
muscle 1
Irs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 58 97.64 Very High Very High Very High
tolerance 45 96.52 Very High Very High Very High
corticosteroid 48 93.68 High High
antagonist 9 89.04 High High
gABA 21 88.48 High High
Inflammation 138 84.56 Quite High
agonist 3 84.36 Quite High
Hippocampus 9 82.52 Quite High
Inflammatory response 16 80.36 Quite High
anesthesia 11 75.88 Quite High
Disease Link Frequency Relevance Heat
Sepsis 252 99.98 Very High Very High Very High
Insulin Resistance 138 99.14 Very High Very High Very High
Obesity 84 98.32 Very High Very High Very High
Diabetes Mellitus 178 97.00 Very High Very High Very High
Hyperinsulinism 4 94.80 High High
Apoptosis 12 89.52 High High
INFLAMMATION 170 84.56 Quite High
Adhesions 4 83.00 Quite High
Infection 16 63.76 Quite High
Disease 6 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present data revealed that insulin + GJG treatment inhibits the increased IRS-1 tyrosine phosphorylation levels (Fig. 5B); therefore, these improvements are thought to improve the abnormal activation of PI 3-kinase (8,9) resulting in the correction of decreased efficiency of glucose metabolization.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1
1) Confidence 0.53 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.35 Pain Relevance 0
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of IRS-1 in adipose tissue associated with obesity and insulin resistance
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.17 Pain Relevance 0.15
Here, we observed that sepsis led to serine phosphorylation of IRS-1 and that atorvastatin reversed this phenomenon in three target tissues, in parallel with a reduction in JNK activity.
Positive_regulation (led) of Phosphorylation (phosphorylation) of IRS-1 associated with sepsis
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.12 Pain Relevance 0.15
Compared with NS ats, LS ats showed reduced (P < 0.01) basal and insulin-stimulated tyrosine phosphorylation of IRS-1 in skeletal muscle and IRS-2 in live, whereas HS ats showed enhanced basal tyrosine phosphorylation of IRS-1 in skeletal muscle (P < 0.05) and of IRS-2 in live.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle
4) Confidence 0.40 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.26 Pain Relevance 0.08
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of IRS-1
5) Confidence 0.39 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.56
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Spec (possibly) Positive_regulation (mediated) of Phosphorylation (phosphorylation) of IRS-1
6) Confidence 0.39 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.57
As shown in Fig. 5B, the abnormal increases in IRS-1 tyrosine phosphorylation induced by STZ (137% of control, P < 0.05) was just about reversed by GJG treatment.


Positive_regulation (increases) of Phosphorylation (phosphorylation) of IRS-1
7) Confidence 0.35 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.35 Pain Relevance 0.03
As shown in Fig. 5B, the abnormal increases in IRS-1 tyrosine phosphorylation induced by STZ (137% of control, P < 0.05) was just about reversed by GJG treatment.


Positive_regulation (induced) of Phosphorylation (phosphorylation) of IRS-1
8) Confidence 0.35 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.35 Pain Relevance 0.03
In liver, IL-6 elevates hepatic glucose output and increases blood glucose by interfering with insulin-induced kinase cascades such as tyrosine phosphorylation of IRS-1 (Senn et al. 2002).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of IRS-1 in blood
9) Confidence 0.32 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.58 Pain Relevance 0.27
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Spec (possibly) Positive_regulation (mediated) of Phosphorylation (phosphorylation) of substrate-1
10) Confidence 0.31 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.57
IRS-1 is phosphorylated in response to insulin, insulin like growth factor-1, and cytokines and is preferentially involved in the metabolic actions of insulin (Gual et al. 2005).
Positive_regulation (phosphorylated) of Phosphorylation (phosphorylated) of IRS-1 associated with cytokine
11) Confidence 0.29 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.52 Pain Relevance 0.18
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
Positive_regulation (induced) of in muscle Phosphorylation (phosphorylation) of IRS-1 in adipose tissue associated with obesity and insulin resistance
12) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.17 Pain Relevance 0.15
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
Positive_regulation (induced) of in liver Phosphorylation (phosphorylation) of IRS-1 in adipose tissue associated with obesity and insulin resistance
13) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.17 Pain Relevance 0.15

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