INT106341

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 18
Total Number 28
Disease Relevance 14.70
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) plasma membrane (Irs1) nucleus (Irs1)
cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
skeletal muscle 6
muscle 4
liver 3
adipose tissue 3
blood 1
Irs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 149 97.64 Very High Very High Very High
tolerance 108 96.04 Very High Very High Very High
Inflammation 369 93.84 High High
corticosteroid 48 93.68 High High
Inflammatory response 44 89.64 High High
gABA 14 88.48 High High
antagonist 6 88.08 High High
anesthesia 29 87.20 High High
Opioid 4 83.00 Quite High
agonist 2 81.36 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 310 99.92 Very High Very High Very High
Sepsis 693 99.70 Very High Very High Very High
Obesity 232 99.08 Very High Very High Very High
Diabetes Mellitus 346 98.92 Very High Very High Very High
Hyperinsulinism 11 94.80 High High
INFLAMMATION 457 93.84 High High
Apoptosis 33 89.52 High High
Adhesions 11 82.52 Quite High
Endotoxemia 22 70.76 Quite High
Infection 44 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we observed that sepsis led to serine phosphorylation of IRS-1 and that atorvastatin reversed this phenomenon in three target tissues, in parallel with a reduction in JNK activity.
Phosphorylation (phosphorylation) of IRS-1 associated with sepsis
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.12 Pain Relevance 0.14
In septic animals, insulin resistance was accompanied by a reduction in insulin-induced IR, IRS-1 tyrosine phosphorylation and in insulin-induced Akt phosphorylation, in liver, muscle and adipose tissue.
Phosphorylation (phosphorylation) of IRS-1 in adipose tissue associated with obesity and insulin resistance
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.16 Pain Relevance 0.14
We also investigated Ser307 phosphorylation of IRS-1 in liver, muscle, and adipose tissue in the four groups of rats.
Spec (investigated) Phosphorylation (phosphorylation) of IRS-1 in muscle associated with obesity
3) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.63 Pain Relevance 0.03
Several studies suggest that JNK contributes to insulin resistance by phosphorylating IRS-1 at serine 307, and this phosphorylation leads to inhibition of IRS-1 function [26], [27], [30], [33], [61], [62], [63], [64], although this has very recently been questioned [65].
Phosphorylation (phosphorylating) of IRS-1 associated with insulin resistance
4) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.91 Pain Relevance 0.16
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Phosphorylation (phosphorylation) of IRS-1
5) Confidence 0.63 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.53
Although we have not assessed the effect on the activation of PI 3-kinase, it was previously described that PI 3-kinase activation closely correlates with IRS-1 phosphorylation in skeletal muscle of STZ-diabetes (46).
Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle associated with diabetes mellitus
6) Confidence 0.63 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.38 Pain Relevance 0
The present data revealed that insulin + GJG treatment inhibits the increased IRS-1 tyrosine phosphorylation levels (Fig. 5B); therefore, these improvements are thought to improve the abnormal activation of PI 3-kinase (8,9) resulting in the correction of decreased efficiency of glucose metabolization.
Phosphorylation (phosphorylation) of IRS-1
7) Confidence 0.63 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.30 Pain Relevance 0
STZ-diabetes is associated with large increases in insulin-stimulated IRS-1 tyrosine phosphorylation (8,9,18), despite the decreased levels of total IRS-1 protein in skeletal muscle (8,18).
Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle associated with diabetes mellitus
8) Confidence 0.62 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.53 Pain Relevance 0
Our results showed that insulin combined with GJG treatment significantly increases the amount of the IRS-1 protein (Fig. 5A) and inhibits its increased tyrosine phosphorylation level more than insulin alone.
Phosphorylation (phosphorylation) of IRS-1 protein
9) Confidence 0.62 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.48 Pain Relevance 0
In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation, by measuring the GLUT4 protein in plasma membrane and microsome, before and after insulin injection; and 3) insulin signaling, by analyzing basal and insulin-stimulated tyrosine phosphorylation of insulin receptor (IR)-beta, insulin receptor substrate (IRS)-1, and IRS-2.
Phosphorylation (phosphorylation) of IRS in plasma
10) Confidence 0.61 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.15 Pain Relevance 0.09
In the sepsis group, insulin-induced IR and IRS-1 tyrosine phosphorylation were decreased in liver, muscle and adipose tissue when compared with sham rats and these alterations were reversed by atorvastatin (Fig. 2A–F).
Phosphorylation (phosphorylation) of IRS-1 in muscle associated with obesity and sepsis
11) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.60 Pain Relevance 0.07
IRS-1 is phosphorylated in response to insulin, insulin like growth factor-1, and cytokines and is preferentially involved in the metabolic actions of insulin (Gual et al. 2005).
Phosphorylation (phosphorylated) of IRS-1 associated with cytokine
12) Confidence 0.52 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.52 Pain Relevance 0.18
In liver, IL-6 elevates hepatic glucose output and increases blood glucose by interfering with insulin-induced kinase cascades such as tyrosine phosphorylation of IRS-1 (Senn et al. 2002).
Phosphorylation (phosphorylation) of IRS-1 in blood
13) Confidence 0.52 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.58 Pain Relevance 0.26
Insulin resistance in rats induced by excess fructose was associated with the impaired insulin receptor (IR), tyrosine autophosphorylation, and insulin receptor substrate (IRS)-1 protein content in addition to the significant decrease in IRS-1 tyrosine phosphorylation in soleus muscle.
Phosphorylation (phosphorylation) of IRS-1 in muscle associated with insulin resistance
14) Confidence 0.49 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.45 Pain Relevance 0.21
Apart from IR protein levels, infusion of beta-endorphin reversed the decrease in protein expression for the IRS-1, p85 regulatory subunit of PI3-kinase, and Akt serine phosphorylation in soleus muscle in fructose-fed rats.
Phosphorylation (phosphorylation) of IRS-1 in soleus
15) Confidence 0.48 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.38 Pain Relevance 0.15
The same trend was found in IRS-1 tyrosine phosphorylation.
Phosphorylation (phosphorylation) of IRS-1
16) Confidence 0.48 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.35 Pain Relevance 0
As shown in Fig. 5B, the abnormal increases in IRS-1 tyrosine phosphorylation induced by STZ (137% of control, P < 0.05) was just about reversed by GJG treatment.


Phosphorylation (phosphorylation) of IRS-1
17) Confidence 0.48 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.35 Pain Relevance 0.03
Compared with NS ats, LS ats showed reduced (P < 0.01) basal and insulin-stimulated tyrosine phosphorylation of IRS-1 in skeletal muscle and IRS-2 in live, whereas HS ats showed enhanced basal tyrosine phosphorylation of IRS-1 in skeletal muscle (P < 0.05) and of IRS-2 in live.
Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle
18) Confidence 0.47 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.25 Pain Relevance 0.08
Compared with NS ats, LS ats showed reduced (P < 0.01) basal and insulin-stimulated tyrosine phosphorylation of IRS-1 in skeletal muscle and IRS-2 in live, whereas HS ats showed enhanced basal tyrosine phosphorylation of IRS-1 in skeletal muscle (P < 0.05) and of IRS-2 in live.
Phosphorylation (phosphorylation) of IRS-1 in skeletal muscle
19) Confidence 0.47 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.25 Pain Relevance 0.07
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Phosphorylation (phosphorylation) of substrate-1
20) Confidence 0.42 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.52

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