INT106343

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 3 89.04 High High
gABA 7 85.16 High High
agonist 1 84.36 Quite High
Hippocampus 3 82.52 Quite High
tetrodotoxin 1 68.16 Quite High
Inflammatory mediators 2 61.28 Quite High
Central nervous system 1 55.60 Quite High
Neurotransmitter 1 51.60 Quite High
Angina 2 50.00 Quite Low
imagery 2 15.68 Low Low
Disease Link Frequency Relevance Heat
Atherosclerosis 26 98.92 Very High Very High Very High
Infarction 2 93.44 High High
Apoptosis 6 90.52 High High
Myocardial Infarction 12 86.88 High High
Acute Coronary Syndrome 4 83.92 Quite High
Coronary Artery Disease 26 75.76 Quite High
INFLAMMATION 4 61.28 Quite High
Cv General 3 Under Development 2 50.00 Quite Low
Syndrome 18 28.60 Quite Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Spec (possibly) Positive_regulation (mediated) of Positive_regulation (activation) of IGF-I
1) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.56
Because of how little is known about the process, it is still difficult to draw conclusions about the mechanism that might account for the significantly higher levels of IGF-1 in patients with advanced coronary atherosclerosis (preliminary data).
Spec (might) Positive_regulation (account) of Positive_regulation (levels) of IGF-1 associated with atherosclerosis
2) Confidence 0.44 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.78 Pain Relevance 0
First, elevated levels of GH could account for the increased levels of IGF-1.
Positive_regulation (account) of Positive_regulation (increased) of IGF-1
3) Confidence 0.44 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.67 Pain Relevance 0.03
This suggests that some residual GH secretion is necessary for the sex steroids to increase IGF I.
Positive_regulation (necessary) of Positive_regulation (increase) of IGF I
4) Confidence 0.08 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2474832 Disease Relevance 0 Pain Relevance 0

General Comments

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