INT106345

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) extracellular space (Igf1)
extracellular region (Igf1) lipid metabolic process (Acot1) cytoplasm (Acot1)
Anatomy Link Frequency
hippocampus 2
Igf1 (Rattus norvegicus)
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 6 98.28 Very High Very High Very High
tetrodotoxin 2 98.24 Very High Very High Very High
antagonist 6 97.68 Very High Very High Very High
gABA 14 97.20 Very High Very High Very High
Central nervous system 2 91.40 High High
Neurotransmitter 2 87.40 High High
agonist 2 70.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, in contrast to ACh release, IGF-I did not alter either the activity of the enzyme ChAT or the uptake of choline in the hippocampus.
IGF-I Neg (not) Regulation (alter) of Localization (release) of ACh in hippocampus associated with hippocampus
1) Confidence 0.06 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.54
The effects of IGF-I on hippocampal ACh release was sensitive to the Na(+) channel blocker tetrodotoxin, suggesting that IGF-I might act indirectly via the release of other transmitters/modulators.
IGF-I Regulation (effects) of Localization (release) of ACh associated with tetrodotoxin
2) Confidence 0.06 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.47

General Comments

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