INT106359
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Effects of urokinase-type plasminogen activator in the acquisition, expression and reinstatement of cocaine-induced conditioned-place preference. | |||||||||||||||
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As neither immunoreactivity for uPA nor uPA-mediated proteolysis was observed, we further examined the effects of tPA on dorsal horn excitability and neuropathic pain behaviour. | |||||||||||||||
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Baseline uPA levels (0.41 to 0.56 ng/mL; P >.05, analysis of variance with repeated measures) were similar among the three groups. uPA levels did not change after surgery in systemic or regional blood samples in any group. | |||||||||||||||
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One of the key regulators of this process is the serine protease, urokinase plaminogen activator (uPA), which converts the zymogen plasminogen into active plasmin. | |||||||||||||||
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It is also reported that the highly expressed uPA in the epidermal of damaged tissue is regulated by FGF-2 which affects MAPK kinase kinase (MEKK-1) and MEKK-1's downstream NH2-terminal kinases (JNK), and extracellular signal-regulated (ERK) for controlling uPA activity [2224]. | |||||||||||||||
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Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated. | |||||||||||||||
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Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity. | |||||||||||||||
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Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity. | |||||||||||||||
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Sunagawa et al. (22) demonstrated the possible role of urokinase-type plasminogen activator and inhibitor in the pathogenesis of ACPs in their study. | |||||||||||||||
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General Comments
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