INT106359

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2002
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.51
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plau) signal transduction (Plau) extracellular space (Plau)
extracellular region (Plau) kinase activity (Plau)
Anatomy Link Frequency
blood 1
dorsal horn 1
Plau (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 6 97.84 Very High Very High Very High
cocaine 14 96.80 Very High Very High Very High
Dorsal horn 5 96.56 Very High Very High Very High
Neuropathic pain 2 95.40 Very High Very High Very High
Sciatic nerve 20 91.80 High High
anesthesia 1 89.24 High High
intrathecal 1 88.56 High High
Peripheral nerve injury 3 84.84 Quite High
Dorsal horn neuron 2 79.60 Quite High
long-term potentiation 1 77.60 Quite High
Disease Link Frequency Relevance Heat
Metastasis 4 98.60 Very High Very High Very High
Polyps 64 98.48 Very High Very High Very High
Hypersensitivity 7 97.72 Very High Very High Very High
Neuropathic Pain 2 95.40 Very High Very High Very High
Disease 7 93.24 High High
Rhinitis 5 88.92 High High
Nervous System Injury 3 84.84 Quite High
Cancer 4 83.44 Quite High
Nociception 1 83.28 Quite High
Maxillary Sinusitis 2 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of urokinase-type plasminogen activator in the acquisition, expression and reinstatement of cocaine-induced conditioned-place preference.
Regulation (Effects) of urokinase associated with cocaine
1) Confidence 0.45 Published 2008 Journal Behav. Brain Res. Section Title Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.43
As neither immunoreactivity for uPA nor uPA-mediated proteolysis was observed, we further examined the effects of tPA on dorsal horn excitability and neuropathic pain behaviour.
Neg (neither) Regulation (immunoreactivity) of uPA in dorsal horn associated with neuropathic pain and dorsal horn
2) Confidence 0.35 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.54 Pain Relevance 0.80
Baseline uPA levels (0.41 to 0.56 ng/mL; P >.05, analysis of variance with repeated measures) were similar among the three groups. uPA levels did not change after surgery in systemic or regional blood samples in any group.
Neg (not) Regulation (change) of uPA in blood
3) Confidence 0.31 Published 2002 Journal J. Vasc. Surg. Section Abstract Doc Link 12422101 Disease Relevance 0.07 Pain Relevance 0.09
One of the key regulators of this process is the serine protease, urokinase plaminogen activator (uPA), which converts the zymogen plasminogen into active plasmin.
Regulation (regulators) of urokinase plaminogen activator
4) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.27 Pain Relevance 0.04
It is also reported that the highly expressed uPA in the epidermal of damaged tissue is regulated by FGF-2 which affects MAPK kinase kinase (MEKK-1) and MEKK-1's downstream NH2-terminal kinases (JNK), and extracellular signal-regulated (ERK) for controlling uPA activity [22–24].
Regulation (controlling) of uPA
5) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Regulation (regulated) of urokinase plasminogen activator associated with metalloproteinase
6) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.05
Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity.
Regulation (changes) of uPA
7) Confidence 0.13 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.11 Pain Relevance 0
Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity.
Regulation (changes) of uPA
8) Confidence 0.13 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.11 Pain Relevance 0
Sunagawa et al. (22) demonstrated the possible role of urokinase-type plasminogen activator and inhibitor in the pathogenesis of ACPs in their study.
Spec (possible) Regulation (role) of urokinase-type plasminogen activator associated with polyps
9) Confidence 0.02 Published 2010 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2896733 Disease Relevance 2.35 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox