INT106359

Context Info Confidence 0.45 First Reported 2002 Last Reported 2011 Negated 2 Speculated 1 Reported most in Body Documents 7 Total Number 9 Disease Relevance 3.51 Pain Relevance 1.50

peptidase activity (Plau) signal transduction (Plau) extracellular space (Plau) extracellular region (Plau) kinase activity (Plau)

Anatomy Link Frequency blood 1 dorsal horn 1 Plau (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 6 97.84 cocaine 14 96.80 Dorsal horn 5 96.56 Neuropathic pain 2 95.40 Sciatic nerve 20 91.80 anesthesia 1 89.24 intrathecal 1 88.56 Peripheral nerve injury 3 84.84 Dorsal horn neuron 2 79.60 long-term potentiation 1 77.60

Disease Link Frequency Relevance Heat Metastasis 4 98.60 Polyps 64 98.48 Hypersensitivity 7 97.72 Neuropathic Pain 2 95.40 Disease 7 93.24 Rhinitis 5 88.92 Nervous System Injury 3 84.84 Cancer 4 83.44 Nociception 1 83.28 Maxillary Sinusitis 2 78.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Effects of urokinase-type plasminogen activator in the acquisition, expression and reinstatement of cocaine-induced conditioned-place preference.

Regulation (Effects) of urokinase associated with cocaine

1) Confidence 0.45 Published 2008 Journal Behav. Brain Res. Section Title Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.43

As neither immunoreactivity for uPA nor uPA-mediated proteolysis was observed, we further examined the effects of tPA on dorsal horn excitability and neuropathic pain behaviour.

Neg (neither) Regulation (immunoreactivity) of uPA in dorsal horn associated with neuropathic pain and dorsal horn

2) Confidence 0.35 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14750967 Disease Relevance 0.54 Pain Relevance 0.80

Baseline uPA levels (0.41 to 0.56 ng/mL; P >.05, analysis of variance with repeated measures) were similar among the three groups. uPA levels did not change after surgery in systemic or regional blood samples in any group.

Neg (not) Regulation (change) of uPA in blood

3) Confidence 0.31 Published 2002 Journal J. Vasc. Surg. Section Abstract Doc Link 12422101 Disease Relevance 0.07 Pain Relevance 0.09

One of the key regulators of this process is the serine protease, urokinase plaminogen activator (uPA), which converts the zymogen plasminogen into active plasmin.

Regulation (regulators) of urokinase plaminogen activator

4) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.27 Pain Relevance 0.04

It is also reported that the highly expressed uPA in the epidermal of damaged tissue is regulated by FGF-2 which affects MAPK kinase kinase (MEKK-1) and MEKK-1's downstream NH2-terminal kinases (JNK), and extracellular signal-regulated (ERK) for controlling uPA activity [22–24].

Regulation (controlling) of uPA

5) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0

Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (tPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.

Regulation (regulated) of urokinase plasminogen activator associated with metalloproteinase

6) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.05

Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity.

Regulation (changes) of uPA

7) Confidence 0.13 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.11 Pain Relevance 0

Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity.

Regulation (changes) of uPA

8) Confidence 0.13 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.11 Pain Relevance 0

Sunagawa et al. (22) demonstrated the possible role of urokinase-type plasminogen activator and inhibitor in the pathogenesis of ACPs in their study.

Spec (possible) Regulation (role) of urokinase-type plasminogen activator associated with polyps

9) Confidence 0.02 Published 2010 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2896733 Disease Relevance 2.35 Pain Relevance 0.09

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