INT106363

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) aging (Tyms)
mRNA binding (Tyms) nucleolus (Tyms) nucleus (Tyms)
Tyms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 2 84.36 Quite High
cva 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 19 95.00 High High
Cancer 13 87.68 High High
Toxicity 24 5.00 Very Low Very Low Very Low
Diarrhoea 21 5.00 Very Low Very Low Very Low
Metastasis 13 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Vomiting 11 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 3 5.00 Very Low Very Low Very Low
Disease Progression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of these treatments, fluoropyrimidines are the most often used and best investigated drugs [2,3]. 5-Fluorouracil (5-FU)-based chemotherapy, – usually biomodulated with folinic acid (FA) to increase its affinity for thymidylate synthase [4] -, was associated with an approximate doubling of the median survival compared to routine standard of care [5].
Positive_regulation (increase) of thymidylate synthase
1) Confidence 0.02 Published 2004 Journal BMC Cancer Section Body Doc Link PMC497044 Disease Relevance 0.30 Pain Relevance 0
These include oral 5-fluorouracil analogues, pure thymidylate synthase inhibitors, dihydropyrimidine dehydrogenase inhibitors, and agents with mechanism of action unrelated to thymidylate synthase such as irinotecan, a topoisomerase I inhibitor, and oxaliplatin, the only platinum derivative with significant activity in colorectal cancer.
Positive_regulation (unrelated) of thymidylate synthase associated with colon cancer
2) Confidence 0.01 Published 2002 Journal Semin. Oncol. Section Abstract Doc Link 12422306 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

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