INT106394

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MAPK3, ADRBK1) cytosol (MAPK3, ADRBK1) nucleoplasm (MAPK3)
mitochondrion (MAPK3) aging (ADRBK1) Golgi apparatus (MAPK3)
MAPK3 (Homo sapiens)
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 3 99.08 Very High Very High Very High
MU agonist 1 98.56 Very High Very High Very High
Kinase C 3 89.20 High High
orphanin 2 84.04 Quite High
agonist 2 75.00 Quite High
opioid receptor 1 54.60 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 57.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we demonstrate for the first time a role for ERK1/2-mediated GRK2 induction in the development of tolerance to mu agonists, as well as cross-tolerance to OFQ/N.
ERK1 Positive_regulation (induction) of GRK2 associated with mu agonist and tolerance
1) Confidence 0.48 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.06 Pain Relevance 0.53

General Comments

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