INT106397

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1, ADRBK1) cytosol (ADRBK1) signal transduction (ADRBK1)
aging (ADRBK1) cytoplasm (ADRBK1) signal transducer activity (OPRL1)
Anatomy Link Frequency
SH-SY5Y 2
OPRL1 (Homo sapiens)
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 85.48 High High
opioid receptor 1 84.20 Quite High
tolerance 3 82.96 Quite High
orphanin 2 76.88 Quite High
Kinase C 3 66.48 Quite High
MU agonist 1 37.92 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 1 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged ORL1 activation increased GRK2 levels and desensitized both receptors in SH-SY5Y cells.
Positive_regulation (activation) of ORL1 in SH-SY5Y Positive_regulation (increased) of GRK2
1) Confidence 0.46 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.09 Pain Relevance 0.31

General Comments

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