INT106401

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.07
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRL1) signal transducer activity (OPRL1)
Anatomy Link Frequency
amygdala 4
C cells 2
OPRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 4 99.96 Very High Very High Very High
Kinase C 3 99.40 Very High Very High Very High
cannabis 6 98.12 Very High Very High Very High
Opioid 11 97.48 Very High Very High Very High
alcohol 6 97.36 Very High Very High Very High
Spinal cord 1 94.44 High High
orphanin 4 93.64 High High
insula 2 87.60 High High
Nicotine 2 83.68 Quite High
Dynorphin 3 82.80 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 67.40 Quite High
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein kinase C (PKC), but not ERK1/2, inhibition blocked OFQ/N-mediated GRK3 induction and mu and ORL1 receptor desensitization in BE(2)-C cells.
Negative_regulation (blocked) of Gene_expression (desensitization) of ORL1 receptor in C cells associated with kinase c
1) Confidence 0.40 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.07 Pain Relevance 0.52
This is the first report describing the expression and characterization of an amphibian ORL1 receptor, and contributes to our understanding of the evolution of the opioid system.
Negative_regulation (describing) of Gene_expression (expression) of ORL1 receptor associated with opioid
2) Confidence 0.38 Published 2005 Journal J. Mol. Endocrinol. Section Abstract Doc Link 15691892 Disease Relevance 0 Pain Relevance 0.68
Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen.
Negative_regulation (reduced) of Gene_expression (expression) of kappa receptor mRNA in amygdala associated with cannabis and amygdala
3) Confidence 0.21 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.86
Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen.
Negative_regulation (reduced) of Gene_expression (expression) of kappa receptor mRNA in amygdala associated with cannabis and amygdala
4) Confidence 0.21 Published 2006 Journal Pharmacogenomics J. Section Abstract Doc Link 16477274 Disease Relevance 0 Pain Relevance 0.85

General Comments

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