INT106404

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADRBK1) signal transduction (ADRBK1) aging (ADRBK1)
plasma membrane (ADRBK1) cytoplasm (ADRBK1)
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 5 99.98 Very High Very High Very High
agonist 3 97.24 Very High Very High Very High
tolerance 3 94.76 High High
opioid receptor 5 93.76 High High
Enkephalin 1 88.72 High High
Kinase C 4 81.36 Quite High
Opioid 1 75.00 Quite High
Antinociceptive 1 66.52 Quite High
Hyperalgesia 1 64.64 Quite High
orphanin 4 64.60 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 3 90.48 High High
Hyperalgesia 1 64.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that DAMGO activation of mu-opioid receptors results in GRK2 and GRK3 inactivation of ORL1 upon challenge with OFQ/N.
Positive_regulation (results) of Positive_regulation (inactivation) of GRK2 associated with mu opioid receptor
1) Confidence 0.41 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.76
Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure.
Positive_regulation (contributes) of Positive_regulation (Induction) of protein-coupled receptor kinases 2 associated with agonist
2) Confidence 0.37 Published 2002 Journal Neuropharmacology Section Title Doc Link 12423667 Disease Relevance 0.09 Pain Relevance 0.31

General Comments

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