INT106422

Context Info Confidence 0.43 First Reported 2002 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 3.97 Pain Relevance 3.41

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1) cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)

Anatomy Link Frequency spine 2 external 2 nociceptors 2 eyelids 2 Rac1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 17 100.00 local anesthetic 5 99.90 nociceptor 1 98.60 Dorsal horn 3 98.16 Neuropathic pain 11 96.20 Hippocampus 8 96.12 hyperexcitability 2 95.78 Spinal cord 69 93.64 Myofascial pain syndrome 1 91.60 painful pain 3 88.96

Disease Link Frequency Relevance Heat Pain 11 100.00 Frailty 10 99.48 Contusions 1 99.22 Dyskinesias 2 98.44 Dystonia 1 97.88 Hemifacial Spasm 1 97.08 Neuropathic Pain 13 96.20 Myofascial Pain Syndromes 1 91.60 Nociception 4 90.00 Spinal Cord Injury 34 83.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To determine whether SCI-induced dendritic spine remodeling contributes to neuronal hyperexcitability and neuropathic pain, we analyzed spine morphometry, localization, and functional influence in dorsal horn (DH) neurons in adult rats 1 month after sham surgery, contusion SCI, and SCI treated with a selective inhibitor of Rac1 activation, NSC23766.

Negative_regulation (inhibitor) of Gene_expression (activation) of Rac1 in spine associated with frailty, dorsal horn, neuropathic pain, contusions and hyperexcitability

1) Confidence 0.43 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19052208 Disease Relevance 1.32 Pain Relevance 0.69

We investigated the efficacy of an eutectic mixture of local anesthetics (EMLA) in reducing the pain of a botulinum toxin injection into eyelids. 17 patients with facial dyskinesia (9 blepharospasm and 8 hemifacial spasm) who had been treated regularly with botulinum toxin injections received EMLA cream and placebo.

Negative_regulation (reducing) of Gene_expression (injection) of botulinum toxin in eyelids associated with pain, hemifacial spasm, dystonia, dyskinesias and local anesthetic

2) Confidence 0.37 Published 2002 Journal Ophthalmologica Section Abstract Doc Link 12424403 Disease Relevance 0.56 Pain Relevance 0.84

Although the precise mechanism of pain relief is not completely understood, the injection of botulinum toxin may reduce various substances that sensitize nociceptors.

Spec (may) Negative_regulation (reduce) of Gene_expression (injection) of botulinum toxin in nociceptors associated with pain and nociceptor

3) Confidence 0.34 Published 2002 Journal Clin J Pain Section Abstract Doc Link 12569966 Disease Relevance 1.67 Pain Relevance 1.64

CONCLUSION: A single injection of botulinum toxin into the anal sphincter seems to be effective in rapidly controlling the pain associated with thrombosed external haemorrhoids, and could represent an effective conservative treatment for this condition.

Negative_regulation (effective) of Gene_expression (injection) of botulinum toxin in external

4) Confidence 0.34 Published 2008 Journal Br J Surg Section Body Doc Link 18844269 Disease Relevance 0.14 Pain Relevance 0

They were transfected with recombinant adenoviruses to express constitutive active (CA) or dominant negative (DN) forms of RhoA, Rac1, or Cdc42 under the control of the CAG promoter, along with marker genes (?

Negative_regulation (forms) of Gene_expression (express) of Rac1

5) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.28 Pain Relevance 0.23

General Comments

This test has worked.