INT106433

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.93
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR5) plasma membrane (CCR5) cell-cell signaling (CCR5)
cytoplasm (CCR5) signal transducer activity (CCR5)
Anatomy Link Frequency
mononuclear phagocytes 1
CCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 136 100.00 Very High Very High Very High
Crohn's disease 2 100.00 Very High Very High Very High
cva 1 100.00 Very High Very High Very High
antagonist 185 99.96 Very High Very High Very High
Opioid 5 99.92 Very High Very High Very High
Inflammation 146 99.66 Very High Very High Very High
Morphine 3 98.60 Very High Very High Very High
fibrosis 3 95.28 Very High Very High Very High
agonist 24 94.88 High High
opioid receptor 2 92.32 High High
Disease Link Frequency Relevance Heat
Disease 64 100.00 Very High Very High Very High
Thrombosis 1 100.00 Very High Very High Very High
INFLAMMATION 151 99.66 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 579 99.24 Very High Very High Very High
Infection 161 99.06 Very High Very High Very High
Disease Progression 6 98.44 Very High Very High Very High
Asthma 315 98.40 Very High Very High Very High
Deafness 1 97.36 Very High Very High Very High
Death 3 97.04 Very High Very High Very High
Sickle Cell Anemia 1 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present report, we sought to examine the capacity of mu- and delta-opioids to modulate the function of chemokine receptors CCR5 and CXCR4, the two major human immunodeficiency virus (HIV) coreceptors.
Spec (examine) Regulation (modulate) of chemokine receptors CCR5 associated with chemokine, acquired immune deficiency syndrome or hiv infection and opioid
1) Confidence 0.59 Published 2003 Journal J. Leukoc. Biol. Section Abstract Doc Link 12972507 Disease Relevance 0.35 Pain Relevance 0.52
Similarly, there are differences in the prevalence of common disorders and associated genetic variants in human populations, such as the factor V Leiden (venous thromboembolic disease [16], [17]), variants in the CARD15 gene (Crohn's disease [18], [19]), the CCR5–?
Regulation (prevalence) of CCR5 associated with crohn's disease, cva and disease
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747275 Disease Relevance 1.26 Pain Relevance 0.18
Consequences of CCR5 antagonist treatment
Regulation (Consequences) of CCR5 associated with antagonist
3) Confidence 0.43 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.33 Pain Relevance 0.20
With greater understanding of the role and impact of the CCR5 receptor in the transmission and progression of HIV-1 disease, numerous efforts to pharmacologically target the CCR5 receptor began.
Regulation (target) of CCR5 receptor associated with acquired immune deficiency syndrome or hiv infection and disease
4) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.32 Pain Relevance 0
As previously discussed, targeting CCR5 leaves a patient without the role of the CCR5 receptor in innate immunity.
Regulation (targeting) of CCR5
5) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.32 Pain Relevance 0.27
Monoclonal antibodies targeting CCR5 have also been developed with CCR5mAb004 of Human Genome Sciences (Rockville, MD, USA), and PRO 140 of Progenics Pharmaceuticals (Tarrytown, NY, USA) progressing to early phase human trials.
Regulation (targeting) of CCR5
6) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 0.21 Pain Relevance 0.08
Therefore, the CCR5 coreceptor is a novel target for prevention of HIV replication and disease progression.
Regulation (target) of CCR5 coreceptor associated with acquired immune deficiency syndrome or hiv infection and disease progression
7) Confidence 0.26 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012555 Disease Relevance 0.77 Pain Relevance 0.20
The profile for PDCs, both pre and post surgery, showed increased levels for CCR6 (pre: median 405, post: median 440, control: median 166) (Figure 5C) and CCR7 (pre: median 3.2, post: median 3.2, control: median 0) (Figure 5D), but no effect was seen for CCR5 (Figure 5B).
Neg (no) Regulation (effect) of CCR5
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.65 Pain Relevance 0.38
It is the CCR5 chemokine receptor targeted by the FDA-approved drug, maraviroc (Selzentry®, Pfizer, New York, NY, USA) (Bartlett et al 2006) HIV-encoded enzymes include a reverse transcriptase (RT), integrase, and protease (PR) that are encoded by the pol gene.
Regulation (targeted) of CCR5 chemokine receptor associated with chemokine and acquired immune deficiency syndrome or hiv infection
9) Confidence 0.14 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504066 Disease Relevance 0.94 Pain Relevance 0.12
resulted in an up-regulation of the chemokine receptors CCR3 and CCR5 in HBMECs which in turn may have enhanced the toxic interaction with the viral envelope protein [88].
Regulation (regulation) of CCR5 associated with chemokine
10) Confidence 0.14 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.78 Pain Relevance 0.11
In an animal model of asthma AOP-RANTES/CCL5 decreases allergen-induced airway inflammation suggesting that targeting CCR5 may also be effective [100].


Regulation (targeting) of CCR5 associated with asthma and inflammation
11) Confidence 0.12 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.80 Pain Relevance 0.45
Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor.
Regulation (modulation) of CCR5 receptor in mononuclear phagocytes associated with chemokine, acquired immune deficiency syndrome or hiv infection, infection and morphine
12) Confidence 0.08 Published 2002 Journal J. Investig. Med. Section Title Doc Link 12425430 Disease Relevance 0.20 Pain Relevance 0.24

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