INT106444

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 13.74
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PHB2) nucleus (PHB2) cytoplasm (PHB2)
Anatomy Link Frequency
nucleus 1
T cell 1
PHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 824 100.00 Very High Very High Very High
qutenza 10 99.98 Very High Very High Very High
Analgesic 3 99.80 Very High Very High Very High
Inflammation 16 92.88 High High
Root ganglion neuron 1 90.16 High High
Angina 1 50.00 Quite Low
Tendonitis 8 35.28 Quite Low
cytokine 14 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 646 100.00 Very High Very High Very High
Gastroenteritis 321 100.00 Very High Very High Very High
Disease 240 100.00 Very High Very High Very High
Chlamydia Infection 128 99.00 Very High Very High Very High
Arthropathy 40 97.40 Very High Very High Very High
Arthralgia 48 96.92 Very High Very High Very High
Infection 66 96.68 Very High Very High Very High
Arthritis 178 95.64 Very High Very High Very High
Nociception 1 93.68 High High
INFLAMMATION 8 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus.
prohibitin 2 Binding (binds) of in nucleus associated with qutenza
1) Confidence 0.48 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 19116139 Disease Relevance 0.63 Pain Relevance 1.18
ROS were closely associated with the distribution of p22(phox) and oxidized LDL.
p22 Binding (associated) of
2) Confidence 0.35 Published 2002 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 12426213 Disease Relevance 0 Pain Relevance 0
Increased duration of care was associated with increasing age for both the specific ReA (Cochran Armitage Trend p < 0.001) and non-specific (p < 0.001) arthropathy/arthralgia outcomes with the following proportion receiving care at least 2 years after initial diagnosis (specific ReA: ?
ReA Binding (associated) of associated with arthralgia, arthropathy and arthritis
3) Confidence 0.20 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 1.12 Pain Relevance 0.43
However, like the functional gastrointestinal postinfectious disorders, the morbidity associated with ReA needs to be considered by providers and policy makers when assessing the impact associated with deployment of countermeasures, in order to mitigate the effects of acute enteric infections during deployment.
ReA Binding (associated) of associated with infection and arthritis
4) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 1.01 Pain Relevance 0.24
The burden of ReA and strong association with antecedent IGE warrants continued IGE prevention efforts.



ReA Binding (association) of associated with gastroenteritis and arthritis
5) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Abstract Doc Link PMC2944352 Disease Relevance 1.57 Pain Relevance 0.41
In summary, we found that ReA was more prevalent than previously recognized in the U.S. active duty military population, especially when non-specific ReA cases were considered.
ReA Binding (recognized) of associated with arthritis
6) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 0.63 Pain Relevance 0.14
Previously considered a self-limited disease, the potential of ReA to cause prolonged, recurrent, or erosive disease has increasingly been recognized[2,3,5,7,9-11].
ReA Binding (recognized) of associated with disease and arthritis
7) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 2.61 Pain Relevance 0.52
Cases were identified using ICD-9 codes associated with ReA that met case definitions as described in Table 1.
ReA Binding (associated) of associated with arthritis
8) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 1.30 Pain Relevance 0.28
The intent of this study was to provide estimates of the incidence and morbidity associated with IGE-related ReA in the U.S. military population.


ReA Binding (associated) of associated with gastroenteritis and arthritis
9) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Abstract Doc Link PMC2944352 Disease Relevance 1.62 Pain Relevance 0.37
The considerable health-care associated costs and decreased quality of life associated with ReA and other IGE sequelae could represent an important consideration to further justify efforts aimed at decreasing the incidence of IGE among US military.


ReA Binding (associated) of associated with gastroenteritis and arthritis
10) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 2.23 Pain Relevance 0.42
Four of six HLA-B27+ Ct-ReA patients had specific synovial T cell binding to at least one HLA-B27/Chlamydia peptide tetramer.
ReA Binding (binding) of in T cell associated with chlamydia infection
11) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064864 Disease Relevance 1.03 Pain Relevance 0.08

General Comments

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