INT106446

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.38
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PHB2) nucleus (PHB2) cytoplasm (PHB2)
Anatomy Link Frequency
coronary artery 1
PHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 313 100.00 Very High Very High Very High
antagonist 1 98.44 Very High Very High Very High
backache 1 87.28 High High
Angina 1 50.00 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
Tendonitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 247 100.00 Very High Very High Very High
Necrosis 1 98.06 Very High Very High Very High
Cancer 1 97.88 Very High Very High Very High
Arthropathy 15 97.40 Very High Very High Very High
Arthralgia 18 96.92 Very High Very High Very High
Disease 89 93.84 High High
Gastroenteritis 120 92.48 High High
Arthritis 66 91.96 High High
Rheumatic Diseases 1 88.04 High High
Low Back Pain 4 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy of tumor necrosis factor antagonists in other spondyloarthritis suggested that anticytokine therapy could also be effective for ReA.
Positive_regulation (effective) of ReA associated with necrosis, cancer, antagonist and arthritis
1) Confidence 0.66 Published 2005 Journal Curr Rheumatol Rep Section Abstract Doc Link 15918996 Disease Relevance 1.10 Pain Relevance 0.43
CONCLUSIONS: ROS generated by p22(phox)-based NADH/NADPH oxidase likely mediate the oxidative modification of LDL and might play a major role in pathogenesis of atherosclerotic coronary artery disease.


Positive_regulation (-based) of p22 in coronary artery
2) Confidence 0.48 Published 2002 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 12426213 Disease Relevance 0 Pain Relevance 0
Deployment to a high risk area was associated with an increased risk of specific ReA (OR: 2.07; 95% CI: 1.36, 3.15).
Positive_regulation (increased) of ReA associated with arthritis
3) Confidence 0.33 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 1.11 Pain Relevance 0.42
Increased duration of care was associated with increasing age for both the specific ReA (Cochran Armitage Trend p < 0.001) and non-specific (p < 0.001) arthropathy/arthralgia outcomes with the following proportion receiving care at least 2 years after initial diagnosis (specific ReA: ?
Positive_regulation (increasing) of ReA associated with arthralgia, arthropathy and arthritis
4) Confidence 0.27 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 1.11 Pain Relevance 0.43
Similar increases were seen for specific ReA diagnoses, from 0.99 per 100,000 (95%CI 0.52-1.82) in the < 20 age group, to 7.09 per 100,000 (95% CI 5.70 - 8.72) in the > 40 age group.
Positive_regulation (increases) of ReA associated with arthritis
5) Confidence 0.22 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2944352 Disease Relevance 1.05 Pain Relevance 0.34

General Comments

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