INT106459

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Context Info
Confidence 0.24
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.08
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 1
SLC10A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 11 99.92 Very High Very High Very High
Pain 13 99.40 Very High Very High Very High
Inflammation 22 92.28 High High
antagonist 4 80.24 Quite High
Inflammatory response 10 78.24 Quite High
visual analogue scale 1 73.20 Quite High
Dismenorea 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myalgia 4 99.68 Very High Very High Very High
INFLAMMATION 32 92.28 High High
Pain 5 87.00 High High
Rhinitis 10 70.52 Quite High
Hyperplasia 5 66.96 Quite High
Nociception 1 54.28 Quite High
Confusion 2 52.88 Quite High
Virilism 1 50.64 Quite High
Congenital Adrenal Hyperplasia 26 16.32 Low Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alpha-1 EEG powers at P3, Pz, P4, PC1, PC2 and POz, and alpha-2 at Pz and POz sites were significantly decreased during muscle pain when compared with aversive noise stimulation.
Negative_regulation (decreased) of P4 in muscle associated with pain and myalgia
1) Confidence 0.24 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12428146 Disease Relevance 0.60 Pain Relevance 0.81
-reduction of 21-carbon pregnanes P4 and 17-OHP, followed by 3?
Negative_regulation (reduction) of P4
2) Confidence 0.14 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.05 Pain Relevance 0
Thus, it has been hypothesized that withdrawal of P4 inhibition is the major mechanism in the initiation of conditioning phase [2].
Negative_regulation (inhibition) of P4 associated with withdrawal
3) Confidence 0.11 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.22 Pain Relevance 0.18
P4 levels were high during pregnancy and at parturition, with a sharp decrease on D1PP.
Negative_regulation (decrease) of P4
4) Confidence 0.10 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.21 Pain Relevance 0.07

General Comments

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